I someone knowledgable about the current possibilities of reaction
prediction software ?

I remember that Professor Gasteiger and colleagues were doing a lot of
resarch in this direction in the 1980s.
http://www2.chemie.uni-erlangen.de/people/Johann_Gasteiger/

Recently, I saw that there is also some software available
http://www.sciencebase.com/CAESA_software.html
(http://www.simbiosys.ca/)

I would be happy getting some additional links.
Best regards
Michael Engel