Pyrosequencing is a method of DNA sequencing (determining the order of
nucleotides in DNA) based on the "sequencing by synthesis" principle, which
relies on detection of pyrophosphate release on nucleotide incorporation rather
than chain termination with dideoxynucleotides.The technique was developed by
Pål Nyrén and his student Mostafa Ronaghi at the Royal Institute of Technology
in Stockholm in 1996.

http://bioisolutions.blogspot.com/2009/05/pyrosequencing.html