> DRSG August 1 Teleconference Agenda
> 1.  Discuss ideas for October Open Forum
> 2.  By-Laws and elections
> 3.  Recruit volunteers to plan mixer, business meeting
>
> Dial In:  (202)260-7280, 3:30-4:30 pm
> Access code:  0577#
>
> ************************
> Peg Coleman
> USDA/FSIS/OPHS
> Epi & Risk Assessment Division
> Rm. 3718 FCB
> 1400 Independence Ave, SW
> Washington, DC 20250-3700
> (202)501-7379
>               -6982 fax
> peg.coleman@...
> ************************
>
>
> ------------------------------------------------------------------------
> Never lose a file again. Protect yourself from accidental deletes,
> overwrites, and viruses with @Backup.
> Try @Backup it's easy, it's safe, and it's FREE!
> Click here to receive 300 MyPoints just for trying @Backup.
> http://click.egroups.com/1/5669/8/_/_/_/962305145/
> ------------------------------------------------------------------------
>
> Hitting "reply" to a message will only reply to
> the author of the message.
>
> To post to this group, send an e-mail to:
> <mailto: DRSG@egroups.com>
>
> To unsubscribe from this group, send an email to:
> <mailto: DRSG-unsubscribe@egroups.com>
>
>

We would like to remind you of this upcoming event.

Teleconference

Date: Tuesday, August 1, 2000
Time: 3:30PM - 4:30PM UTC (GMT+00:00)

Call in:  (202)260-7280
Access Number:  0577#

Proposed Agenda

1.  More ideas for future Open Forum topics and speakers

2.  More ideas for symposia/workshops (Paul Schlosser)
     adverse effects update  (Jim Wilson)
     deadline for SRA meeting submissions, May 15
3.  Other business

The following is a forwarded message.  Please send any
responses/inquiries to Dr. Byrd.

-Paul Schlosser


>Date: Sat, 29 Jul 2000 12:16:45 -0400
>From: Daniel Byrd <ctraps@...>
>X-Mailer: Mozilla 4.61 [en] (Win98; I)
>Subject: Re: Workshop Announcement
>X-MIME-Autoconverted: from 8bit to quoted-printable by mail1.radix.net id
MAA23150
>
>Paul,
>
>Please repost the announcement below at the CIIT site (meetings
>announcements) or other sites you think appropriate.  I have already posted
>to BioMechModel@egroups.com
>
>Thanks,
>
>dbyrd
>

---
The Society for Risk Analysis, the Electric Power Research Institute,
Resources for the Future, and the U.S. Environmental Protection Agency will
present the following  workshop,.

ADVANCED METHODS FOR DOSE-RESPONSE ASSESSMENT:
BAYESIAN APPROACHES

On September 18-20, 2000, at the Conference Center of Resources for the
Future, 1616 P Street, NW, Washington, DC 20036

Make plans now to join us for this informative event.  Seating is limited,
so please register early.  Reduced fee registrations are available until
8/14/00.

Visit the Society for Risk Analysis web site at www.sra.org and download a
pdf file with registration information.  To link directly to the
announcement, click on http://www.sra.org/events.htm#workshop

This three-day workshop is intended to identify methods to satisfy an unmet
need in human health risk assessment, estimating responses at low doses.
Most current assessments use some kind of upper bound on response.  Such
estimates are useful for many purposes, but sometimes an unbiased estimate
is needed.  The organizers (primarily James D. Wilson of Resources for the
Future and Annie Jarabek of the U.S. Environmental Protection Agency)
suggest that approaches based on Bayesian logic may lead to low-dose
estimates of response and offer the workshop to explore this possibility.
The workshop will begin with an introduction to Bayesian analysis, for
persons unfamiliar with the methods, and will cover applications of Bayesian
methods in medical research, space exploration, exposure assessment, and
ecological risk.  The workshop will explore the use of Bayesian methods in
modeling dose-response relationships and integrating disparate data in
dose-response estimation.  It will conclude with discussion of future
directions and research needs.

Some of the invited speakers and their proposed topics are:

William Farland; U.S. Environmental Protection Agency - Purpose and
Importance of the Workshop.

Thomas Louis; University of Minnesota - Theory of Bayesian Logic and
Statistics – Introduce Concepts, Illustrate Range of Uses, Describe
Limitations.

Kevin Brand; University of Ottawa - Using Readily-Available Software to
Compute Posteriors, Given Appropriate Input.

D. Warner North; Northworks - Applying Bayesian Logic in a Decision Context
– Review Theory; Describe Application to Relevant Decisions.

Donald Berry; M.D. Anderson Cancer Center - Use of Bayesian Approaches in
Medical Research – Clinical Trials – Illustrate Use, Need to Identify
Appropriate Priors.

Alison Cullen; University of Washington - Identifying Inputs.

Mitchell Small; Carnegie-Mellon University - Using Dispararate Data in
Exposure Assessment.

Igor Linkoff; Menzie-Cura Associates - Application to Ecological Risk .
Illustrate Use, Illustrate How to Deal With Errors in Data.

L. Anthony Cox; Cox Associates - Bayesian Risk Assessment: Combining
Evidence from Multiple Sources.

Daniel Byrd; CTRAPS - Constructing an Exposure-Response Function.

R. Wyzga; Electric Power Research Institute - Issues in Estimating
Dose-response Functions.

Annie Jarabek; US Environmental Protection Agency and Vic Hasselblad; Duke
University -  Using a Bayesian Approach to Integrate Data.

Donald Barnes; U.S. Environmental Protection Agency - Where Do We Go From
Here? Applications and Research Needs.

---
Daniel M. Byrd III, Ph.D., D.A.B.T.
President,
Consultants in Toxicology, Risk Assessment and Product Safety
Suite N707
560 N Street, SW
Washington, DC 20024
(202)484-7707 - phone
(202)484-0616 - fax
ctraps@... - email

> DRSG August 1 Teleconference Agenda
> 1.  Discuss ideas for October Open Forum
> 2.  By-Laws and elections
> 3.  Recruit volunteers to plan mixer, business meeting
>
> Dial In:  (202)260-7280, 3:30-4:30 pm
> Access code:  0577#
>
> ************************
> Peg Coleman
> USDA/FSIS/OPHS
> Epi & Risk Assessment Division
> Rm. 3718 FCB
> 1400 Independence Ave, SW
> Washington, DC 20250-3700
> (202)501-7379
>               -6982 fax
> peg.coleman@...
> ************************
>
>
> ------------------------------------------------------------------------
> Never lose a file again. Protect yourself from accidental deletes,
> overwrites, and viruses with @Backup.
> Try @Backup it's easy, it's safe, and it's FREE!
> Click here to receive 300 MyPoints just for trying @Backup.
> http://click.egroups.com/1/5669/8/_/_/_/962305145/
> ------------------------------------------------------------------------
>
> Hitting "reply" to a message will only reply to
> the author of the message.
>
> To post to this group, send an e-mail to:
> <mailto: DRSG@egroups.com>
>
> To unsubscribe from this group, send an email to:
> <mailto: DRSG-unsubscribe@egroups.com>
>
>

I will be out of the office until July 10, 2000.

We would like to remind you of this upcoming event.

Teleconference

Date: Tuesday, July 4, 2000
Time: 3:30PM - 4:30PM UTC (GMT+00:00)

Call in:  (202)260-7280
Access Number:  0577#

Proposed Agenda

1.  More ideas for future Open Forum topics and speakers

2.  More ideas for symposia/workshops (Paul Schlosser)
     adverse effects update  (Jim Wilson)
     deadline for SRA meeting submissions, May 15
3.  Other business

This is an initial announcement of a one-day symposium on
the Integration of Ecological & Human Health Risk Assessment,
to be held October 30, 2000, at the Friday Center, University
of North Carolina, Chapel Hill, NC.

This event is being organized and sponsored by the Research
Triangle Chapter of the Society of Risk Analysis (RTC-SRA).

Details will be posted in future announcements.  Please feel
free to contact me if you have questions abour or particular
interest in the symposium.

-Paul Schlosser


~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
Paul M. Schlosser
Chemical Industry Institute of Toxicology
E-mail: schlosser@...
Phone: (919) 558-1243
Fax:   (919) 558-1300

Dear Colleagues,

Please note that DRSG will not hold its usual teleconference next Tuesday,
July 4.  A suggested agenda for the next teleconference on August 1 is
listed below after a summary from the Program Committee meeting earlier this
month.  Please review the appended note from our Editor-in-Chief of Risk
Analysis, Betty Anderson, and provide your individual comments to her as
soon as possible.

Summary from SRA Program Committee:  A number of members of DRSG assisted at
this year's Program Committee Meeting on June 9.  A total of 38 submissions
for Dose-Response Assessment were received for the 2000 SRA national
meeting.  DRSG is sponsoring 4 symposia this year, and additional oral,
poster platform, and poster sessions.  The DRSG Mixer is planned for Monday
evening, December 4 immediately after the second afternoon session, and our
DRSG business meeting will be a Tuesday morning brunch on December 5.  A
number of students submitted applications for the DRSG student award.  DRSG
members will continue to be involved in processes this fall to select the
student awardee and recognize the student at the SRA national meeting.


August 1 Teleconference Agenda
1.  Discuss ideas for October Open Forum
2.  Recruit volunteers to plan mixer, business meeting
3.  Begin recruiting a slate of officers for our fall email election

Current Officers are:
President  (Peg Coleman, retiring to Past President after December's
meeting)
Vice President for Program Planning  (Paul Schlosser, President Elect)
Vice President for Education (Lynne Haber)
Acting Secretary/Treasurer AND Past President (Elizabeth Reece)

Executive Committee (Resha Putzrath, Ralph Kodell, Larisa Rudenko)


Request from Risk Analysis Editor-in-Chief, Betty Anderson
I would like to solicit your help with several potential areas involving the
contents of Risk Analysis:  An International Journal.  The editorial staff
join me in vigorously pursuing a breadth of interest and participation
across all the fields covered by the Journal.  In many respects, we feel
that you are closest to the many issues that we wish to have covered by
Journal contributions.  These include the following:

1.  Contribution of high quality research papers for publication (for
example, very few papers have been submitted to the Journal over the past
year from a number of areas including exposure assessment and law and risk
analysis).

2.  Book reviews - to date, your Journal staff has solicited reviewers for
books that have been brought to our attention.  I would like to solicit your
help in identifying books that you feel are deserving of review in the pages
of the Journal and further ask your help in identifying reviewers to make
those submissions.  You will notice the lack of coverage of many topics that
are current issues.

3.  Letters to the Editor and perspective articles are rarely submitted.  We
would like to invite more use  of these types of submissions to cover areas
of particular, current interest to the most important topics of the day in
Risk Analysis.

4.  We are interested in identifying topics of special interest around which
we can invite special collections of papers.  Some of you may know of
particular conferences that might be the source of high quality, special
collection opportunities.  I would like to invite your help.

5.  The editorial staff has decided to seek special topics of current
interest for inviting overview papers and commentary papers in response.  I
would like to seek your help in identifying special topics that you feel
would be of interest to our readership and also in identifying potential
contributors for the overview articles and commentaries.

I appreciate your help and hope that you will be contacting me in the near
future with ideas for contributions from your particular topic areas and
geographic locations.  Thank you for your help.

All the best.

Betty Anderson
Editor-in-Chief

Elizabeth L. Anderson, Ph.D.
President & CEO
Sciences International, Inc.

1800 Diagonal Rd, Suite 500
Alexandria, VA 22314

Tel: 703-684-0123
Fax: 703-684-2223

elanderson@...

************************
Peg Coleman
USDA/FSIS/OPHS
Epi & Risk Assessment Division
Rm. 3718 FCB
1400 Independence Ave, SW
Washington, DC 20250-3700
(202)501-7379
               -6982 fax
peg.coleman@...
************************

> Dear Colleagues,
>
> Reminder:
> June 6 Open Forum, 3:30-4:30 pm
> Call in:  (202)260-7280
> Access Number:  0577#
>
> Open Forum topic:
> Microbial Dose-Response Modeling:  Surrogate Dose-Response Models for the
> Foodborne Pathogen E. coli O157:H7
>
> Introduction:  Attached are two files that will be discussed in the Open
> Forum on Tuesday, June 6.  The first is a PowerPoint file with only six
> slides that summarize the data and the models.  The second is a draft
> manuscript that will be presented on the work at a WHO/FAO consultation
> later this month.  In case you have difficulty opening the PowerPoint
> file, I have copied some of the key figures into this email message.  If
> you cannot read the file or view the figures in your email message, please
> call me and I will fax the figures to you.  It will be helpful for our
> discussion to have the figures in front of you during the Open Forum.
>
> My Agency would greatly appreciate input from DRSG on this work.  If you
> cannot join us for the Open Forum, please comment as soon as possible by
> email to me or to Jim Wilson (wilson@...;
> wilson.jimjudy@...) who is handling the comments from DRSG
> for the author.  Thank you in advance for your confidential review.
>
>  <<June6six.ppt>>
>
>
>  <<O157WHO.DOC>>
>
> Shigella dysenteriae
> strain Dose Frequency   n
> M 131 1.0E+01       0.10 10
> A-1 2.0E+02       0.25   4
> M 131 2.0E+02       0.50   4
> M 131 2.0E+03       0.70 10
> A-1 1.0E+04       0.33   6
> M 131 1.0E+04       0.83   6
>
> EPEC
> Strain Dose Frequency n
> O127 1.0E+06      0.00 4
> O142 1.0E+06      0.20 5
> O142 1.0E+08      0.20 5
> B-171-8 5.0E+08      0.6 5
> B-171-8 2.5E+09      1 6
> O127 1.0E+10      0.60 5
> O142 1.0E+10      1.00 5
> B-171-8 2.0E+10      1 2
>
>  <<...>>
>
>  <<...>>
>
>  <<...>>
>
>
> ************************
> Peg Coleman
> USDA/FSIS/OPHS
> Epi & Risk Assessment Division
> Rm. 3718 FCB
> 1400 Independence Ave, SW
> Washington, DC 20250-3700
> (202)501-7379
>               -6982 fax
> peg.coleman@...
> ************************
>

We would like to remind you of this upcoming event.

Teleconference

Date: Tuesday, June 6, 2000
Time: 3:30PM - 4:30PM UTC (GMT+00:00)

Call in:  (202)260-7280
Access Number:  0577#

Proposed Agenda

1.  More ideas for future Open Forum topics and speakers

2.  More ideas for symposia/workshops (Paul Schlosser)
     adverse effects update  (Jim Wilson)
     deadline for SRA meeting submissions, May 15
3.  Other business

> Dear Colleagues,
>
> Reminder:
> June 6 Open Forum, 3:30-4:30 pm
> Call in:  (202)260-7280
> Access Number:  0577#
>
> Open Forum topic:
> Microbial Dose-Response Modeling:  Surrogate Dose-Response Models for the
> Foodborne Pathogen E. coli O157:H7
>
> Introduction:  Attached are two files that will be discussed in the Open
> Forum on Tuesday, June 6.  The first is a PowerPoint file with only six
> slides that summarize the data and the models.  The second is a draft
> manuscript that will be presented on the work at a WHO/FAO consultation
> later this month.  In case you have difficulty opening the PowerPoint
> file, I have copied some of the key figures into this email message.  If
> you cannot read the file or view the figures in your email message, please
> call me and I will fax the figures to you.  It will be helpful for our
> discussion to have the figures in front of you during the Open Forum.
>
> My Agency would greatly appreciate input from DRSG on this work.  If you
> cannot join us for the Open Forum, please comment as soon as possible by
> email to me or to Jim Wilson (wilson@...;
> wilson.jimjudy@...) who is handling the comments from DRSG
> for the author.  Thank you in advance for your confidential review.
>
>  <<June6six.ppt>>
>
>
>  <<O157WHO.DOC>>
>
> Shigella dysenteriae
> strain Dose Frequency   n
> M 131 1.0E+01       0.10 10
> A-1 2.0E+02       0.25   4
> M 131 2.0E+02       0.50   4
> M 131 2.0E+03       0.70 10
> A-1 1.0E+04       0.33   6
> M 131 1.0E+04       0.83   6
>
> EPEC
> Strain Dose Frequency n
> O127 1.0E+06      0.00 4
> O142 1.0E+06      0.20 5
> O142 1.0E+08      0.20 5
> B-171-8 5.0E+08      0.6 5
> B-171-8 2.5E+09      1 6
> O127 1.0E+10      0.60 5
> O142 1.0E+10      1.00 5
> B-171-8 2.0E+10      1 2
>
>  <<...>>
>
>  <<...>>
>
>  <<...>>
>
>
> ************************
> Peg Coleman
> USDA/FSIS/OPHS
> Epi & Risk Assessment Division
> Rm. 3718 FCB
> 1400 Independence Ave, SW
> Washington, DC 20250-3700
> (202)501-7379
>               -6982 fax
> peg.coleman@...
> ************************
>

With regard to the last comment by Jim, I'd say that a
gamma-multi-hit model would be the most appropriate model to use,
because this accounts directly for multiple discrete failures (to
kill n microbes, or n colony-forming microbial units) required to
permit infection.  This form implies a practical threshold for any
n>1, where in this model the parameter n can be fractional.  -Ken


>TO:  Dose-response Specialty Group
>FROM:  Jim Wilson
>SUBJECT: Comments on Mark Powell paper
>
>I have received comments from four reviewers on the paper sent out
>by Peg Coleman recently.  Rather than send out a summary of the
>comments themselves, I offer here for your consideration a summary
>of some issues these commenters raised.  My intent is to stimulate
>discussion, not to criticize the paper.
>
>In general, the authors have made their assumptions clear, and
>justified them.  However, reviewers identified a few apparent
>assumptions that are critical to the analysis.  These inspire the
>following questions; if the analysts actually made assumptions other
>than those inferred from reading the paper, then their presentation
>needs significant improvement.
>
>1.  The authors of this paper have taken on a very difficult task,
>namely trying to infer an intrinsic dose-response relationship
>between intake of E. coli organisms and the probability of a
>clinically significant illness.  If they are successful in defining
>this relationship, what kinds of risk management decisions might it
>inform?
>
>2.  The analysis appears to assume a causal chain of this kind:  a)
>eating contaminated meat leads to infection, with some probability
>determined by unknown, randomly distributed characteristics of the
>population; b) infection leads to illness, with some probability
>depending on unknown, randomly distributed characteristics of the
>population.  Is this assumption realistic?
>
>3.  The analysis appears to assume that all those who ingest the
>bacteria have an equal chance of becoming infected, i.e., that there
>is a flat dependence of infectedness on dose.  (To put this another
>way:  a "one hit" model is appropriate.)  Is this assumption
>reasonable?
>
>4.  The analysis appears to assume that the form of the distribution
>of bacteria in ingested meat remains unaltered when the meat is
>cooked.  Among other things, this assumes uniform cooking.  (It is
>known that a majority of samples of cooked mean show no detectable
>recoverable E. coli; thus the distribution of "cooked" samples
>includes a large proportion at zero.)  Is this assumption
>reasonable?
>
>5.  The analysis makes use of a form of distribution (beta Poisson)
>that does not permit a threshold.  The reviewers believe that any
>true microbial dose-response must have a threshold, and thus that
>some other functional form should be used.  What do you think?  (The
>data available are very uncertain, and thus are likely to fit almost
>any reasonable model, but not very well.)
>
><http://click.egroups.com/1/4878/7/_/_/_/959913416/>
>
>
>Hitting "reply" to a message will only reply to
>the author of the message.
>
>To post to this group, send an e-mail to:
><mailto: DRSG@egroups.com>
>
>To unsubscribe from this group, send an email to:
><mailto: DRSG-unsubscribe@egroups.com>

______________________________________
Kenneth T. Bogen, Dr.P.H.
Health & Ecological Assessment Division, L-396
Lawrence Livermore National Laboratory, University of California
7000 East Avenue
Livermore, California  94550-9900
Tel: (925) 422-0902;   Fax: (925) 424-3255   E-mail: bogen@...

My apologies:  the characters ³ and ² should be read as "open quote" and
"close quote", respectively.

> -----Original Message-----
> From: Coleman, Peg
> Sent: Thursday, May 11, 2000 10:41 AM
> To: 'DRSG2 ls'
> Subject: DRSG Open Forum, June 6
>
> Dear Colleagues,
>
> Reminder:
> June 6 Open Forum, 3:30-4:30 pm
> Call in:  (202)260-7280
> Access Number:  0577#
>
> Open Forum topic:
> Microbial Dose-Response Modeling:  Surrogate Dose-Response Models for the
> Foodborne Pathogen E. coli O157:H7
>
> Introduction:  The Food Safety and Inspection Service of the US Department
> of Agriculture has supported work on microbial risk assessments for this
> pathogen as a hazard in ground beef since 1996.  The initial work was
> published in Risk Analysis in 1998 (Marks, Risk Analysis 18(3):309-328).
> Currently, a risk assessment project is underway for modeling exposure
> from farm to fork and developing alternative approaches to surrogate
> dose-response modeling.  The attached slide show was presented to the
> National Advisory Committee for Microbiological Criteria in Foods in
> December to vet a series of approaches to Dose-Response modeling.  The
> attached draft manuscript is an extension of one of these approaches that
> is scheduled for presentation to a World Health Organization consultation
> by Dr. Mark Powell the week of June 12.  FSIS would very much appreciate
> confidential peer-review comments from DRSG members on this work to be
> discussed at the June 6 Open Forum.  Even if you cannot participate in the
> June 6 Open Forum, your comments by email or fax on the slide show and the
> draft manuscript would be very valuable as we prepare the work for public
> release.
>
> The PowerPoint presentation in the first file was delivered first to the
> National Advisory Committee on Microbiological Criteria in Foods in
> December of 1999.  A few slides were updated in version six.  Speaker
> notes are included, FYI.  The slide show provides introduction to the
> approach presented in the Word file that will be submitted for the WHO/FAO
> consultation on dose-response modeling for microbial hazards later in June
> of this year.
>
>  <<Dose-Response6.ppt>>
>
>  <<O157WHO.DOC>>
> My Agency would greatly appreciate input from DRSG on this work.  If you
> cannot join us for the Open Forum, please comment as soon as possible by
> email to me or to Jim Wilson (wilson@...;
> wilson.jimjudy@...) who is handling the comments from DRSG
> for the author.  Thank you in advance for your confidential review.
>
>
> ************************
> Peg Coleman
> USDA/FSIS/OPHS
> Epi & Risk Assessment Division
> Rm. 3718 FCB
> 1400 Independence Ave, SW
> Washington, DC 20250-3700
> (202)501-7379
>               -6982 fax
> peg.coleman@...
> ************************
>

Dear Colleagues,

Reminder: symposia proposals and abstracts are due tomorrow, Friday, May 12.

Open Forum topic for June 6:
Microbial Dose-Response Modeling:  Surrogate Dose-Response Models for the
Foodborne Pathogen E. coli O157:H7

Introduction:  The Food Safety and Inspection Service of the US Department
of Agriculture has supported work on microbial risk assessments for this
pathogen as a hazard in ground beef since 1996.  The initial work was
published in Risk Analysis in 1998 (Marks, Risk Analysis 18(3):309-328).
Currently, a risk assessment project is underway for modeling exposure from
farm to fork and developing alternative approaches to surrogate
dose-response modeling.  The attached slide show was presented to the
National Advisory Committee for Microbiological Criteria in Foods in
December to vet a series of approaches to Dose-Response modeling.  The
attached draft manuscript is an extension of one of these approaches that is
scheduled for presentation to a World Health Organization consultation by
Dr. Mark Powell the week of June 12.  FSIS would very much appreciate
confidential peer-review comments from DRSG members on this work to be
discussed at the June 6 Open Forum.  Even if you cannot participate in the
June 6 Open Forum, your comments by email or fax on the slide show and the
draft manuscript would be very valuable as we prepare the work for public
release.

Thank you in advance for your confidential review.

  <<Dose-Response.exe>>  <<O157WHO.DOC>>

Reminder:  June 6 Open Forum, 3:30-4:30 pm
Call in:  (202)260-7280
Access Number:  0577#

************************
Peg Coleman
USDA/FSIS/OPHS
Epi & Risk Assessment Division
Rm. 3718 FCB
1400 Independence Ave, SW
Washington, DC 20250-3700
(202)501-7379
               -6982 fax
peg.coleman@...
************************

Dear DRSG members,

Sorry for the duplication of effort today.  Paul already sent you a list
that is appended as both a file and text copied into this message on the
symposia proposals received to date.  Please review and comment, by email or
on the teleconference to begin shortly.


Reminder:  May 2 Teleconference, 3:30-4:30 pm
Call in:  (202)260-7280
Access Number:  0577#

Proposed Agenda
1.  Input on 8 proposed symposia (Paul Schlosser)

2.  Update on adverse effects project  (Jim Wilson)

3.  Other business
 	 deadline for SRA meeting submissions, May 12
	 listserve issues (rules of engagement?)


Each DRSG member who proposed a symposia will have the opportunity to
briefly present their session and solicit comments on any of the following:
   symposium topic and title,
   introductory material describing the session and its purpose,
   the speakers, and
   the titles for the presentations.


  <<DRSG symp.doc>>

Proposed DRSG Symposia Proposed by May 2, 2000

#1 - Dourson/Haber:  USING HUMAN DATA IN RISK ASSESSMENT TO PROTECT PUBLIC
HEALTH
      The use of human data in the risk assessment and risk management
processes
as defined by the National Academy of Sciences (NAS, 1983) are
investigated. Although the use of such data has a long and successful
history in the risk assessment for environmental contaminants and in the
development of drugs and commercial chemicals, recent deliberations within
the U.S. Environmental Protection Agency (and perhaps elsewhere), have
questioned this practice.
      The purpose of this research is to compare the use of ethically-derived
and
scientifically-credible data from either experimental animals or humans
when deriving "safe" human doses for environmentally-relevant chemicals. We
test the hypothesis that the direct use and interpretation of human data,
in conjunction with data gathered from experimental animals, is a public
health protective policy that should be encouraged.
      Research areas include the comparison of human- and experimental
animal-based risk specific doses (RSDs), reference doses (RfDs), and
Reference Concentrations (RfCs), and the comparison of human and
experimental animal data on toxicokinetics and toxicodynamics. Within the
framework of risk assessment, discussion topics will include whether human
data are to be preferred over data from experimental animals, when is the
use of human data unethical, and what is the public health value of the
estimating the most scientifically credible risk number?

Speakers unspecified to date.

----------------------

#2/3 Rigas/Kissel,   MECHANISTIC EXPOSURE/DOSE MODELING FOR FQPA.

Speakers addressing strictly dermal, not oral or pulmonary absorption and
route-to-route
extrapolation.

1. Zendzian, R.P.  USE OF IN VITRO DERMAL PENETRATION STUDIES TO COMPARE RAT
AND HUMAN PENETRATION OF CHEMICALS

2. Dellarco/Zendzian -

3. Knaak/Dary/Blancato USE OF FOLIAR TRANSFER COEFFICIENTS IN CONJUNCTION
WITH PBPK/PD MODELS IN ASSESSING ABSORBED DOSE AND ChE INHIBITION FROM POST
APPLICATION DERMAL EXPOSURE TO PESTICIDES ON CITRUS AND TURF

4. Hubal - MACROACTIVITY APPROACH IN RESIDENTIAL SETTINGS

5. Maibach, H.I. - TAPE STRIPPING/SKIN COMPARTMENT STORAGE

6. Reddy, M.B., Guy, R.H., Bunge, A.L.; DOES EPIDERMAL TURNOVER REDUCE
PERCUTANEOUS PENETRATION OF PESTICIDES?

7. Reddy, M.B., Bunge, A.L..  DOES SPATIAL DISTRIBUTION OF PESTICIDE
RESIDUES ON THE SKIN SURFACE AFFECT DERMAL ABSORPTION?

8. Kissel, JC, J Shirai, R Showlund, K Elgethun.  INVESTIGATION OF SPATIAL
DISTRIBUTION OF PESTICIDES ON SKIN FOLLOWING CONTACT TRANSFER


------------------

#5 Schlosser  MODEL VALIDATION

1) Amit Roy, and Panos G.  Georgopoulos TOOLS FOR MODEL EVALUATION,
PARAMETER ESTIMATION, DATA ASSIMILATION
      This presentation discusses the assumptions underlying commonly used
metrics of the performance of "prognostic" models (i.e. models based on
physicochemical principles), strategies for improving model performance by
parameter estimation and data assimilation, and tools for selection of an
optimal model from among alternative competing formulations.  The maximum
likelihood objective function is presented as a generalization of the
least-squares, and weighted least-squares objective functions, and
goodness-of-fit metrics such as the chi-square and runs test are discussed.
  Parameter identifiability and pitfalls of parameter estimation by
nonlinear regression are discussed and alternative empirical Bayes methods
of assimilating the information in the data into the model are presented.
Finally, selection of the "best" model using the Akaike Information
Criteria and the Schwarz Information Criteria is discussed.

2) Michael C. Kohn, Nigel J. Walker, Amy H. Kim, and Christopher J. PORTIER
EFFECT OF INCREASING BIOLOGICAL REALISM ON PREDICTIONS OF DOSE-RESPONSE
MODELS. IMPLICATIONS FOR TCDD RISK ASSESSMENT
      A physiological model of effects on gene expression of
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rat liver was extended to
include the increased proteolysis of the Ah receptor on binding TCDD, a
more realistic representation of gene transcription and mRNA translation,
and variable stability among the mRNA molecules. Multiple TCDD-liganded Ah
receptor binding sites for CYP1A1 and CYP1B1 genes, a lag of 0.2 day for
production of mRNA and induced proteins, and stabilization of mRNA by a
poly(A) tail were included as well. Parameters were estimated by formal
optimization to fit observed dose-response patterns for liver TCDD and for
CYP1A1, CYP1A2, and CYP1B1 mRNA and protein after repeated dosing. Because
dose-response data cannot uniquely identify kinetic parameter values, a
wide range of values yields comparable fits to the data. The model
reproduces the transient depletion of the Ah receptor subsequent to binding
ligand and fits the dose-response of the receptor in rats treated with
biweekly oral doses of TCDD in corn oil. The poorer induction of CYP1B1 is
predicted to be due to lower affinity of the dioxin responsive elements for
binding the liganded Ah receptor, suggesting the involvement of other
regulatory factors, and the shorter lifetime of CYP1B1 mRNA due to a
shorter poly(A) tail. Saturation in the kinetics of protein synthesis was
linked to the limited number of ribosomes that could bind to each message
molecule, resulting in fewer ribosomes bound per message at higher doses.
This model predicts a 13-fold lower ED01 for CYP1A2 induction than does a
less detailed model, demonstrating the importance of biological realism in
dose-response modeling.

3) Frederic Bois MODEL VALIDATION VERSUS MODEL CALIBRATION
      It can be argued that the validation of a model is an unachievable
goal. Model calibration, in order to check that a model correctly describe
the data at hand, may be a more practical objective. Validation will be
compared, conceptually to calibration from a decision analysis perspective.
Consequences for regulatory activities will be discussed.

--------------

#6 Coleman/Schlosser  MECHANISTIC CONSIDERATIONS FROM TOXICOLOGY TO
INFECTIOUS DISEASE

       Pharmacokinetic/pharmacodynamic modeling has fueled great advances in
the
fields of toxicology and chemical risk assessment.  The lessons learned by
this generation of mechanistic modelers might provide useful insights to
microbial risk assessors who are considering mechanistic modeling to address
current concerns such as antibiotic resistance and foodborne/waterborne
disease.  The need for mechanistic approaches for microbial dose-response
modeling is apparent from the tremendous uncertainty associated with
limitations of the available data from human and animal clinical trials and
epidemiologic evidence.  The appeal of mechanistic approaches to predict
illness includes the identification of sensitive variables that might be
measured in a human population to develop biologically-based dose-response
relationships for healthy adults and more sensitive sub-populations that
might include infants, children, the elderly, and those with
immuno-suppression or underlying diseases.  The purpose of the symposium is
to begin a dialogue between chemical and microbial risk assessors regarding
both advantages and limitations of mechanistic modeling and also the design
of study protocols that appropriately target the data needs for development
of mechanistic models.

Speakers, affiliation, general topic
1. Rory Conolly, Chemical Industry Institute of Toxicology, RTP
	 LESSONS LEARNED BY PHARMACOKINETIC/PHARMACODYNAMIC MODELERS
2. Judith Hyatt, Clinical Pharmacokinetics Lab, Millard Filmore Health
System, Buffalo, NY
	 PHARMACODYNAMIC MODELING OF RISK FACTORS FOR CIPROFLOXACIN
RESISTANCE
3. Harry Marks, USDA, Food Safety & Inspection Service, Washington, DC
	 THEORETICAL MECHANISTIC MODEL FOR SALMONELLOSIS
4. Chung Kim, FDA, Center for Food Safety & Applied Nutrition, Laurel, MD
              STUDY DESIGN TO MEASURE BIOMARKERS FOR SALMONELLOSIS IN ANIMAL
MODELS

-------------------

#7/8 Jarabek  MODE-OF-ACTION MOTIVATED DOSIMETRY:  EPA INTERAGENCY PROJECT

Session 1.
1) A.M. Jarabek,
EPA NCEA Project overview and objectives:  describes rationale for
harmonization between noncancer and cancer approaches, parallel structures
for
inhalation, oral and dermal; acute versus chronic and location of toxicity,
and hierarchy for default versus data-driven, mode-of-action motivated
alternative dose metric formulations

2) J.N. McDougal, DoD, Geo-Centers
Anatomy and physiology relevant to model development:  for each of the
three routes for which model suites are being developed

3)  L.M. Hanna, Hanna and Associates,
Integrated Risk Management Inhalation route model suites:  describe platform
in RfC methods, additional model structures and rationale of suite for
inhalation route

4)  M. Rigas, EPA NERL-LV
GI uptake model suites:  describes suite of models developed and rationale
for model structures requried to address GI administrations of concern
(physicochemical properties, location of toxicity, vehicle, etc)

Session 2.
5) E. Hubal, EPA NERL-RTP
Dermal absorption model suites:  describes suite of models developed and
rational for structures to address different dermal uptake
(physicochemical, location of toxicity, vehicle, etc)

6) H. Clewell, ICF Kaiser
Tissue compartment considerations for modeling mode-of-action:  describes
details in tissue compartments that can be superimposed on model suites

7) R. B. Conolly, CIIT
Considerations for application of biologically-based models to
mode-of-action:  observations on utility, limitations, etc.

8) Panel discussion:  team members and invited participants (not yet
entirely
selected) to discuss attributes and issues of proposed model suites


************************
Peg Coleman
USDA/FSIS/OPHS
Epi & Risk Assessment Division
Rm. 3718 FCB
1400 Independence Ave, SW
Washington, DC 20250-3700
(202)501-7379
               -6982 fax
peg.coleman@...
************************

Hi all,

Sorry for contributing to the flurry of e-mails here, but below is a
detailed description of the symposium (2 sessions) being organized
by Annie Jarabek.

-Paul Schlosser


>X-Sender: ajarabek@...
>X-Mailer: QUALCOMM Windows Eudora Pro Version 4.2.1
>Date: Tue, 02 May 2000 12:37:27 -0400
>To: schlosser@...
>From: Annie Jarabek <ajarabek@...>
>Subject: Outline of SRA symposium
>
>Paul,
>
>Here is the outline of speakers and topics for the proposed symposium (2
>sessions) on the interagency dosimetry project.  All speakers have been
>contacted and agreed to present.
>
>Mode-of-Action motivated dosimetry:  EPA Interagency Project
>
>Session 1.
>Project overview and objectives:  describes rationale for harmonization
>between noncancer and cancer approaches, parallel structures for
>inhalation, oral and dermal; acute versus chronic and location of toxicity,
>and hierarchy for default versus data-driven, mode-of-action motivated
>alternative dose metric formulations
>A.M. Jarabek, EPA NCEA
>
>Anatomy and physiology relevant to model development:  for each of the
>three routes for which model suites are being developed
>J.N. McDougal, DoD, Geo-Centers
>
>Inhalation route model suites:  describe platform in RfC methods,
>additional model structures and rationale of suite for inhalation route
>L.M. Hanna, Hanna and Associates, Integrated Risk Management
>
>GI uptake model suites:  describes suite of models developed and rationale
>for model structures requried to address GI administrations of concern
>(physicochemical properties, location of toxicity, vehicle, etc)
>M. Rigas, EPA NERL-LV
>
>Session 2.
>Dermal absorption model suites:  describes suite of models developed and
>rational for structures to address different dermal uptake
>(physicochemical, location of toxicity, vehicle, etc)
>E. Hubal, EPA NERL-RTP
>
>Tissue compartment considerations for modeling mode-of-action:  describes
>details in tissue compartments that can be superimposed on model suites
>H. Clewell, ICF Kaiser
>
>Considerations for application of biologically-based models to
>mode-of-action:  observations on utility, limitations, etc.
>R. B. Conolly, CIIT
>
>Panel discussion:  team members and invited participants (not yet entirely
>selected) to discuss attributes and issues of proposed model suites
>____________________________________________________________________________
>
>Annie M. Jarabek
>Visiting Scientist, Respiratory Toxicology Program
>Chemical Industry Institute of Toxicology (CIIT)
>P.O. Box 12137
>6 Davis Drive
>Research Triangle Park, NC  27709
>____________________________________________________
>
>PHONE:  919.558.1429
>FAX:  919.558.1213
>E-MAIL:  ajarabek@...
>____________________________________________________
>
>

Below are listed the draft proposals for symposia for discussion today.

Before commenting on that process, a comment re. subscription to this
e-mail list: as is stated at the bottom of every post, you can unsubscribe
at any time by sending an e-mail to: DRSG-unsubscribe@egroups.com

You also have two other options if you log onto egroups
(http://www.egroups.com/mygroups).  Next to the listing of DRSG on the
'home' tab you can select three options - individual e-mails, daily digest,
or no e-mail at all (but you can check the messages whenever you want on
the web site).  Do consider these options before unsubscribing.

Below are the listings of the symposia proposals I have so far.  Since we
are not asked to screen things by the SRA, unless there is serious objection
I presume that each will be submitted for the program planning.

-Paul

---------------------

Via Marc Rigas:

>To:   Marc Rigas/LV/USEPA/US@EPA, abunge@...
>cc:
>
>Subject:  Re: Mechanistic exposure/dose modeling for FQPA.
>
>
>
>Hi Marc,
>
>Here's our tentative lineup.  Could add or subtract.  Some absorption related
>stuff, but only Knaaak gets to dose to target/toxicology.  But it's
>occupational, not FQPA.  (Still if you are doing a PBPK session that paper
might
>fit better with you than us.)
>
>
>We are strictly dermal, so oral or pulmonary absorption and route-to-route
>extrapolation are still open.
>
>JK
>
>
>
>1. Zendzian, R.P.USE OF IN VITRO DERMAL PENETRATION STUDIES TO COMPARE RAT
AND
>HUMAN PENETRATION OF CHEMICALS
>
>2. Dellarco/Zendzian -
>
>3. Knaak/Dary/Blancato USE OF FOLIAR TRANSFER COEFFICIENTS IN CONJUNCTION
WITH
>PBPK/PD MODELS IN ASSESSING ABSORBED DOSE AND ChE INHIBITION FROM POST
>APPLICATION DERMAL EXPOSURE TO PESTICIDES ON CITRUS AND TURF
>
>4. Hubal - Macroactivity approach in residential settings
>
>5. Maibach, H.I. - tape stripping/skin compartment storage
>
>6. Reddy, M.B., Guy, R.H., Bunge, A.L.; DOES EPIDERMAL TURNOVER REDUCE
>PERCUTANEOUS PENETRATION OF PESTICIDES?
>
>7. Reddy, M.B., Bunge, A.L..  DOES SPATIAL DISTRIBUTION OF PESTICIDE
RESIDUES ON
>THE SKIN SURFACE AFFECT DERMAL ABSORPTION?
>
>8. Kissel, JC, J Shirai, R Showlund, K Elgethun.  INVESTIGATION OF SPATIAL
>DISTRIBUTION OF PESTICIDES ON SKIN FOLLOWING CONTACT TRANSFER
>
>John C. Kissel, Ph.D., P.E.
>Associate Professor
>University of Washington
>Dept. of Environmental Health
>Box 357234
>Seattle, WA 98195-7234
>jkissel@...
>
>voice: (206) 543-5111
>fax: (206) 543-8123
>
---------------------

What Peg and I have been working on:

>From: "Coleman, Peg" <Peg.Coleman@...>
>To: 'drsg p schlosser' <schlosser@...>
>Subject: draft symposium description for comment
>Date: Tue, 2 May 2000 09:39:06 -0400
>X-Mailer: Internet Mail Service (5.5.2650.21)
>
>Mechanistic Considerations from Toxicology to Infectious Disease
>Co-chairs:  Paul Schlosser, Peg Coleman
>
>Pharmacokinetic/pharmacodynamic modeling has fueled great advances in the
>fields of toxicology and chemical risk assessment.  The lessons learned by
>this generation of mechanistic modelers might provide useful insights to
>microbial risk assessors who are considering mechanistic modeling to address
>current concerns such as antibiotic resistance and foodborne/waterborne
>disease.  The need for mechanistic approaches for microbial dose-response
>modeling is apparent from the tremendous uncertainty associated with
>limitations of the available data from human and animal clinical trials and
>epidemiologic evidence.  The appeal of mechanistic approaches to predict
>illness includes the identification of sensitive variables that might be
>measured in a human population to develop biologically-based dose-response
>relationships for healthy adults and more sensitive sub-populations that
>might include infants, children, the elderly, and those with
>immuno-suppression or underlying diseases.  The purpose of the symposium is
>to begin a dialogue between chemical and microbial risk assessors regarding
>both advantages and limitations of mechanistic modeling and also the design
>of study protocols that appropriately target the data needs for development
>of mechanistic models.
>
>Speakers, affiliation, general topic
>1. Rory Conolly, Chemical Industry Institute of Toxicology, Research
>Triangle Park
>  Lessons Learned by Pharmacokinetic/Pharmacodynamic Modelers
>2. Judith Hyatt, Clinical Pharmacokinetics Lab, Millard Filmore Health
>System, Buffalo, NY
>  Pharmacodynamic Modeling of Risk Factors for Ciprofloxacin
>Resistance
>3. Harry Marks, USDA, Food Safety & Inspection Service, Washington, DC
>  Theoretical Mechanistic Model for Salmonellosis
>4. Chung Kim, FDA, Center for Food Safety & Applied Nutrition, Laurel,
>MD
>Study Design to Measure Biomarkers for Salmonellosis in Animal Models
>
>************************
>Peg Coleman
>USDA/FSIS/OPHS
>Epi & Risk Assessment Division
>Rm. 3718 FCB
>1400 Independence Ave, SW
>Washington, DC 20250-3700
>(202)501-7379
>              -6982 fax
>peg.coleman@...
>************************
>
-------------------

From Annie Jarabek:

> -----Original Message-----
> From: /S=Jarabek.Annie@.../O=INTER2/P=GOV+USDA/A=ATTMAIL/C=US/
> [SMTP:/S=Jarabek.Annie#064#epamail.epa.gov/O=INTER2/P=GOV+USDA/A=ATTMAIL/C
> =US/@...]
> Sent: Friday, April 07, 2000 5:29 PM
> To: Peg.Coleman@...
> Subject: Re: Summary April 4 DRSG Teleconference
> Sensitivity: Personal
>
>
>
> Peg,
>
> I have another symposium idea to offer for DRSG group endorsement.   NCEA
> EPA
> has been collaborating with DoD, NIOSH, OSHA, and FDA on an interagency
> dosimetry project.  The objectives are to develop suites of models for
> each
> route of exposure (oral, dermal and inhalation); the various structures in
> the
> suites would correspond to the amount of detail one might have in the
> available
> ADME and MOA data.  The project's goal is to provide this guidance as a
> means of
> harmonizing approaches to dosimetry adjustment between noncancer and
> cancer,
> acute and chronic exposure and to facilitate accurate route-to-route and
> cumulative / aggregate dose calculations.
>
> It is important to us to roll it out at the DC meeting due to the location
> especially.  It would be 2 sessions long, let me know if you need more
> detail.
>
> Cheers,
>
> Annie.
>

----------------------------

I'm also trying to pull something together on model validation.

Speakers I have lined up so far are Amit Roy, Frederic Bois,
and Michael Kohn.  But I need to get two more to make a symposium,
so I'm not sure if I will be able to in time.

1)
Tools for Model Evaluation, Parameter Estimation, Data Assimilation
Amit Roy, and Panos G.  Georgopoulos

This presentation discusses the assumptions underlying commonly used
metrics of the performance of "prognostic" models (i.e. models based on
physicochemical principles), strategies for improving model performance by
parameter estimation and data assimilation, and tools for selection of an
optimal model from among alternative competing formulations.  The maximum
likelihood objective function is presented as a generalization of the
least-squares, and weighted least-squares objective functions, and
goodness-of-fit metrics such as the chi-square and runs test are discussed.
  Parameter identifiability and pitfalls of parameter estimation by
nonlinear regression are discussed and alternative empirical Bayes methods
of assimilating the information in the data into the model are presented.
Finally, selection of the "best" model using the Akaike Information
Criteria and the Schwarz Information Criteria is discussed.


2) Effect of Increasing Biological Realism on Predictions of Dose-response
Models.
	 Implications for TCDD Risk Assessment

	 Michael C. Kohn, Nigel J. Walker, Amy H. Kim, and Christopher J. Portier

	 Laboratory of Computational Biology and Risk Analysis
	 National Institute of Environmental Health Sciences
	 Research Triangle Park, NC 27709

A physiological model of effects on gene expression of
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rat liver was extended to
include the increased proteolysis of the Ah receptor on binding TCDD, a
more realistic representation of gene transcription and mRNA translation,
and variable stability among the mRNA molecules. Multiple TCDD-liganded Ah
receptor binding sites for CYP1A1 and CYP1B1 genes, a lag of 0.2 day for
production of mRNA and induced proteins, and stabilization of mRNA by a
poly(A) tail were included as well. Parameters were estimated by formal
optimization to fit observed dose-response patterns for liver TCDD and for
CYP1A1, CYP1A2, and CYP1B1 mRNA and protein after repeated dosing. Because
dose-response data cannot uniquely identify kinetic parameter values, a
wide range of values yields comparable fits to the data. The model
reproduces the transient depletion of the Ah receptor subsequent to binding
ligand and fits the dose-response of the receptor in rats treated with
biweekly oral doses of TCDD in corn oil. The poorer induction of CYP1B1 is
predicted to be due to lower affinity of the dioxin responsive elements for
binding the liganded Ah receptor, suggesting the involvement of other
regulatory factors, and the shorter lifetime of CYP1B1 mRNA due to a
shorter poly(A) tail. Saturation in the kinetics of protein synthesis was
linked to the limited number of ribosomes that could bind to each message
molecule, resulting in fewer ribosomes bound per message at higher doses.
This model predicts a 13-fold lower ED01 for CYP1A2 induction than does a
less detailed model, demonstrating the importance of biological realism in
dose-response modeling.


3)
Frederic Bois

Model validation versus model calibration

It can be argued that the validation of a model is an unachievable
goal. Model calibration, in order to check that a model correctly describe
the data at hand, may be a more practical objective. Validation will be
compared,
conceptually to calibration from a decision analysis perspective. Consequences
for regulatory activities will be discussed.

We would like to remind you of this upcoming event.

Teleconference

Date: Tuesday, May 2, 2000
Time: 3:30PM - 4:30PM UTC (GMT+00:00)

Call in:  (202)260-7280
Access Number:  0577#

Proposed Agenda

1.  More ideas for future Open Forum topics and speakers

2.  More ideas for symposia/workshops (Paul Schlosser)
     adverse effects update  (Jim Wilson)
     deadline for SRA meeting submissions, May 15
3.  Other business

Given that the system has been very quiet since I've set it up, while
I agree that this is a potential concern I would suggest that we feel
free to use the list for DRSG business and then take corrective action
if there are complaints.  It is possible to have the list moderated.
Another possibility is to allow submission only by the officers.  But
I would rather not stifle discussion that way.

I agree fully that this is worth discussing tomorrow, to set up some
ground-rules.

-Paul


At 12:50 PM 5/1/00 -0500, you wrote:
>All:
>
>I am a little concerned about the possibility for abuse of this convenience
>-- it makes it all too easy for us to send stuff to each other.  I can't
>imagine that any of you are anxious to receive tons of unexpected mail,
>any more so than I am.  Perhaps at tomorrow's meeting-by-telephone we can
>discuss our expectations for courteous behavior on DRSG members' part.
>
>For instance, there exists a short document written by Clark Carrington and
>Mike Bolger that I would like your responses to -- if any.  But I don't want
>to start circulating this kind of stuff without our giving permission to
>each other to do so.
>
>Thanks.
>
>Jim
>

Reminder:  May 2 Teleconference, 3:30-4:30 pm
Call in:  (202)260-7280
Access Number:  0577#

Proposed Agenda
1.  More ideas for future Open Forum topics and speakers

2.  More ideas for symposia/workshops (Paul Schlosser)
	 adverse effects update  (Jim Wilson)

3.  Other business
 	 deadline for SRA meeting submissions, May 12
	 listserve issues (rules of engagement?)

  ************************
  Peg Coleman
  USDA/FSIS/OPHS
  Epi & Risk Assessment Division
  Rm. 3718 FCB
  1400 Independence Ave, SW
  Washington, DC 20250-3700
  (202)501-7379
                -6982 fax
  peg.coleman@...
  ************************


************************
Peg Coleman
USDA/FSIS/OPHS
Epi & Risk Assessment Division
Rm. 3718 FCB
1400 Independence Ave, SW
Washington, DC 20250-3700
(202)501-7379
               -6982 fax
peg.coleman@...
************************

All:

I am a little concerned about the possibility for abuse of this convenience
-- it makes it all too easy for us to send stuff to each other.  I can't
imagine that any of you are anxious to receive tons of unexpected mail, any
more so than I am.  Perhaps at tomorrow's meeting-by-telephone we can
discuss our expectations for courteous behavior on DRSG members' part.

For instance, there exists a short document written by Clark Carrington and
Mike Bolger that I would like your responses to -- if any.  But I don't want
to start circulating this kind of stuff without our giving permission to
each other to do so.

Thanks.

Jim

Colleagues,

And thanks to Peg for the clarification.  This list/web-site has further
potential that we can tap.  For example, there is a calendar, and I have
just added our monthly telecon (first Tues of each month, 3:30-4:30) to
the calendar, with a (generic) reminder to be sent 12 hours before the
call-in.  Details of the agenda can be added/edited each month.  There's
also a page for links, so you can add links to websites related to the
interests of our group.  Right now I *think* that any member can go in
and edit these items, but let me know if you have trouble with it.

Also, I do suggest that members fill in their professional contact info
in the 'phonebook' to help us keep in touch with each other.
(http://www.egroups.com/database/DRSG?method=reportRows&tbl=1)

-Paul Schlosser
CIIT

> Dear Colleagues,
>
> Thanks, Ken Bogen, for asking for clarification on the list-serve options
> from DRSG and the wider community.
>
> At the April 4 DRSG conference call, our Program VP, Paul Schlosser,
> offered to set up two list-serves, the first targeting our nearly 80
> current DRSG members, the second for a different, but overlapping,
> audience targeting those with interests in mechanistic modeling.  These
> list-serve options will also be described in the upcoming Risk Newsletter.
>
> In the past, the Presidents of DRSG had each set up a distribution list
> for our large membership, and sent email through that distribution list
> several times a month to communicate needs and activities of DRSG.  The
> list-serve seems a more efficient mechanism for communication amongst our
> members.  Paul has already set up the DRSG list-serve, and automatically
> "subscribed" everyone on the DRSG email list.  If you find that you do not
> want to continue on the DRSG list-serve, you can un-subscribe.
>
> This latest message from Paul (appended) regards the second list-serve,
> BioMechModel.  Paul is not automatically "subscribing" anyone to this
> second list-serve.  If you are interested, please go to
> (http://www.egroups.com/group/BioMechModel) and register.
>
> Kudos to Paul for taking the initiative to upgrade our IT capacity in
> DRSG.  Please join us on our next teleconference call on Tuesday, May 2.
>
>
> Reminder:  May 2 Teleconference, 3:30-4:30 pm
> Call in:  (202)260-7280
> Access Number:  0577#
>
> Proposed Agenda
> 1.  More ideas for future Open Forum topics and speakers
>
> 2.  More ideas for symposia/workshops (Paul Schlosser)
>  adverse effects update  (Jim Wilson)
>
> 3.  Other business
>  deadline for SRA meeting submissions, May 15
>
> ************************
> Peg Coleman
> USDA/FSIS/OPHS
> Epi & Risk Assessment Division
> Rm. 3718 FCB
> 1400 Independence Ave, SW
> Washington, DC 20250-3700
> (202)501-7379
>               -6982 fax
> peg.coleman@...
> ************************
>
>
> -----Original Message-----
> From: Ken Bogen
> [SMTP:/S=bogen#064#llnl.gov/O=INTER2/P=GOV+USDA/A=ATTMAIL/C=US/@...
> v]
> Sent: Tuesday, April 11, 2000 5:27 PM
> To: /S=DRSG@egroups.com/O=INTER2/P=GOV+USDA/A=ATTMAIL/C=US/
> Subject: Re: [DRSG] BioMechModel@egroups.com
> Sensitivity: Personal
>
> Is this a group separate from DSRG, or is it part of DSRG? -Ken Bogen
>
>
> >Colleagues,
> >
> >(Apologies if you receive this message multiple times, but I am trying to
> >promote this group broadly.)
> >
> >This is an *invitation* to join another list that I've set up, the
> >BioMechModel e-mail list.  The purpose of that list is to promote
> >discussion, announcements, and information exchange among people doing
> >mechanistically-based mathematical modeling for the understanding,
> >elucidation, and prediction of adverse health effects of foreign agents
> >(chemicals, radiation, particles, etc).  This is meant to be a
> >cross-disciplinary group, open to all, irrespective of professional
> >affiliation, so while I anticipate considerable overlap with the DRSG
> list,
> >the two lists will serve different purposes
> >
> >To join, you must go to the URL
> (http://www.egroups.com/group/BioMechModel)
> >and register by with your e-mail address and by choosing a password.
> There
> >will also be a "phonebook" under the "Database" link where you can enter
> >contact info for yourself.  (You may also want to put some info in your
> >eGroups profile.)
> >
> >The posting address for the group is: BioMechModel@egroups.com.
> >
> >Looking forward to future discussions!
> >
> >-Paul Schlosser
> >CIIT
> >
> >
> >------------------------------------------------------------------------
> >  You have a voice mail message waiting for you at iHello.com:
> >http://click.egroups.com/1/2936/4/_/_/_/955485060/
> >------------------------------------------------------------------------
> >
> >To unsubscribe from this group, send an email to:
> >DRSG-unsubscribe@egroups.com
>
> ______________________________________
> Kenneth T. Bogen, Dr.P.H.
> Health & Ecological Assessment Division, L-396
> Lawrence Livermore National Laboratory, University of California
> 7000 East Avenue
> Livermore, California  94550-9900
> Tel: (925) 422-0902;   Fax: (925) 424-3255   E-mail: bogen@...
>
> ------------------------------------------------------------------------
>  You have a voice mail message waiting for you at iHello.com:
> http://click.egroups.com/1/2936/4/_/_/_/955488496/
> ------------------------------------------------------------------------
>
> To unsubscribe from this group, send an email to:
> DRSG-unsubscribe@egroups.com
>
>

Is this a group separate from DSRG, or is it part of DSRG? -Ken Bogen


>Colleagues,
>
>(Apologies if you receive this message multiple times, but I am trying to
>promote this group broadly.)
>
>This is an *invitation* to join another list that I've set up, the
>BioMechModel e-mail list.  The purpose of that list is to promote
>discussion, announcements, and information exchange among people doing
>mechanistically-based mathematical modeling for the understanding,
>elucidation, and prediction of adverse health effects of foreign agents
>(chemicals, radiation, particles, etc).  This is meant to be a
>cross-disciplinary group, open to all, irrespective of professional
>affiliation, so while I anticipate considerable overlap with the DRSG list,
>the two lists will serve different purposes
>
>To join, you must go to the URL (http://www.egroups.com/group/BioMechModel)
>and register by with your e-mail address and by choosing a password.  There
>will also be a "phonebook" under the "Database" link where you can enter
>contact info for yourself.  (You may also want to put some info in your
>eGroups profile.)
>
>The posting address for the group is: BioMechModel@egroups.com.
>
>Looking forward to future discussions!
>
>-Paul Schlosser
>CIIT
>
>
>------------------------------------------------------------------------
>  You have a voice mail message waiting for you at iHello.com:
>http://click.egroups.com/1/2936/4/_/_/_/955485060/
>------------------------------------------------------------------------
>
>To unsubscribe from this group, send an email to:
>DRSG-unsubscribe@egroups.com

______________________________________
Kenneth T. Bogen, Dr.P.H.
Health & Ecological Assessment Division, L-396
Lawrence Livermore National Laboratory, University of California
7000 East Avenue
Livermore, California  94550-9900
Tel: (925) 422-0902;   Fax: (925) 424-3255   E-mail: bogen@...

Colleagues,

(Apologies if you receive this message multiple times, but I am trying to
promote this group broadly.)

This is an *invitation* to join another list that I've set up, the
BioMechModel e-mail list.  The purpose of that list is to promote
discussion, announcements, and information exchange among people doing
mechanistically-based mathematical modeling for the understanding,
elucidation, and prediction of adverse health effects of foreign agents
(chemicals, radiation, particles, etc).  This is meant to be a
cross-disciplinary group, open to all, irrespective of professional
affiliation, so while I anticipate considerable overlap with the DRSG list,
the two lists will serve different purposes

To join, you must go to the URL (http://www.egroups.com/group/BioMechModel)
and register by with your e-mail address and by choosing a password.  There
will also be a "phonebook" under the "Database" link where you can enter
contact info for yourself.  (You may also want to put some info in your
eGroups profile.)

The posting address for the group is: BioMechModel@egroups.com.

Looking forward to future discussions!

-Paul Schlosser
CIIT

>Hi all,
>
>This is just a test of the system.  You should have received an
>invitation message, though in fact you are already signed up.
>Hopefully this will ease future communication!
>
>-Paul
>
>
>
>------------------------------------------------------------------------
>Whatever you want, chances are you'll find it at one of the hundreds
>of sites in The PointClick Network--like Disney.com, eCost.com,
>FogDog.com and many more. You get paid as you shop and an additional
>10% off any purchase, anytime.
>http://click.egroups.com/1/2994/4/_/_/_/955402007/
>------------------------------------------------------------------------
>
>To unsubscribe from this group, send an email to:
>DRSG-unsubscribe@egroups.com

Got it. -KB

______________________________________
Kenneth T. Bogen, Dr.P.H.
Health & Ecological Assessment Division, L-396
Lawrence Livermore National Laboratory, University of California
7000 East Avenue
Livermore, California  94550-9900
Tel: (925) 422-0902;   Fax: (925) 424-3255   E-mail: bogen@...

Hi all,

This is just a test of the system.  You should have received an
invitation message, though in fact you are already signed up.
Hopefully this will ease future communication!

-Paul