Dear Colleagues I agree with Kenny that we should look at these questions more broadly. For example, toxic effects are known by toxicologists to have...
Mike Dourson
dourson@...
May 1, 2009 6:41 pm
904
Mike, Not sure if you mean to assert that `*some* toxic effects are known by toxicologists to have thresholds *under some circumstances*' or whether you are...
Kevin Brand
kbrand@...
May 1, 2009 7:30 pm
905
Thanks Jim. That is helpful. The evidence you cite would appear to support a "some toxic effects are believed to have thresholds under some circumstances,"...
Kevin Sorry to be tardy in response to your nice inquiry. The basic tenet of toxicology is that ³All substances are poisons; there is none which is not a ...
Michael Dourson
dourson@...
May 5, 2009 5:08 pm
908
The Society of Toxicology Risk Analysis Specialty Section (SOT RASS) will be hold a teleseminar Wednesday, May 13, 2009 from 3:00 - 4:30 entitled "Science and...
Feder, Paul I
feder@...
May 5, 2009 7:11 pm
909
Mike, I can hardly control myself not to join this dicussion (as you may imagine), but I have some other priorities right now. I just wanted to pose one...
On "thresholds": from a practical standpoint, there will always be some level of exposure below which the incidence of adverse health effects in any 'exposed'...
Please comment on proposed sessions, topics, speakers. I like the idea of having a DRSG track at this year's meeting, with the microbial sessions to follow...
Coleman, Peg
pcoleman@...
May 6, 2009 4:17 pm
912
Michael, Thanks for your reply. It helps me get a better understanding of your position, and challenges me to better articulate mine. I too have spoken with...
Kevin Brand
kbrand@...
May 7, 2009 9:17 pm
913
If you would do a repeated dose study with a mixture of say 20 or 30 OP esters, each of them at their own NOAEL, I can garantee you that there will be...
Wout Thanks for your thoughtful comments. I do not have time right now for any in-kind response due to a pending workshop on developing RfDs for acetanilide...
Michael Dourson
dourson@...
May 8, 2009 12:09 pm
915
As a minor addendum to Kevin's comments, I would like to point out that even when (or if) if thresholds do exist, setting quantitative bounds for them is ...
Kenny Crump
KennyCrump@...
May 8, 2009 2:17 pm
916
I have been reading through this thread and have decided to jump in. I have been teaching a tox class for the last two years and have taken the approach that...
I just can't resist jumping in on this discussion. Theoretical work by Lutz et al. and the work that I did with several colleagues on formaldehyde while at...
... P.P.S. The argument that thresholds exist "because Paracelsus said so" sounds to me like the argument "because God said so", but you are forgiven. By the...
januszb@...
May 10, 2009 6:25 am
921
Attached is a reminder about the teleseminar this Wednesday. Also attached is the slide presentation, thanks to Annie Jarabek of SOT/RASS. Please remember to...
Feder, Paul I
feder@...
May 10, 2009 1:52 pm
922
The DRSG is a great group. I’ve read all the posts to this discussion in order, now and have had three cups of coffee (one would not be enough; five would...
Lipscomb.John@...
May 11, 2009 12:23 pm
923
Dear All: I have been tracking this discussion or the last few weeks and I think that we are in danger of talking past one another. On the one hand there are...
Dear Janusz, There might be some misunderstanding due to the (false) idea that a dose-response either has a threshold, or it is linear. My point is that...
... molecule of a mutagenic carcinogen producing cancer? Without doubt, there is a probability...">> John: Sure, you are right, but there is also a...
januszb@...
May 11, 2009 2:48 pm
926
All, It looks like we will have lots of fodder for our September teleseminar, which will include a discussion of thresholds as they relate to the NAS 2008...
Just to keep the pot boiling a little longer and not to let Paul P have the last word: In Paul's example, if no precursors were seen in the five animals, I...
Kenny Crump
KennyCrump@...
May 12, 2009 11:00 pm
928
Catching up on back emails... A microbial session would be especially interesting this year, given the swine-flu outbreak. But it should probably focus some...
I've mainly been a lurker on this, and have not had time to be on conference calls. But I am sure that I and others (including Peg) could develop a...
Chuck Haas
haas@...
May 13, 2009 2:24 pm
930
DRSG, Attached are the minutes from the May 5, 2009 conference call. Please let me know if they require any revisions or additions. Also, remember that the...
The June meeting will be a teleseminar relating to the NAS report, continuing from the March teleseminar. The teleseminar will be held on June 9. This is a...
Having problems with message search?
Fill out this form to ensure your group is one of the first to be migrated to the new message search system.
