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Here are some data on 4 litters that were presumed to be NTD. I hope I've got everything right.
*1999*
(I saw this litter IRL)
----
7 kits, 4 with head/brain and spinal defects, difficult prolonged delivery, the 4 affected were all stillborn and so was also one normal looking kit, the remaining 2 appeared normal but died after a couple of days, they were never able to get the jill to nurse them well
---
Sire: sable b. 1997
Dam: sable b. 1998
The sire was from a fur farm and had an all sable background. Grand parents and great grand parents of the dam are known and sable.
*2000*
(per owner‘s description + photos)
---
6 kits, 3 with hydrocephalus (euthanized), 1 missing parts of the brain (flat head) and protruding eyes (stillborn), 2 looked normal but were euthanized
---
Sire: sable b. 1999
Dam: sable b. 1999
Grandparents: sable
Closest unknown are the great grand parents of both sire and dam.
*2001*
(per owner's description + photos)
---
4 kits, all with spina bifida, 1 or 2 had a rather large exposed area on the spine, all were dead within 24 hours if I remember correctly
---
Sire: sable b. ?
Dam: sable b. 1998
I don’t know the background.
*2004*
( per owner's description)
----
5 kits, 4 with spina bifida died shortly after birth, the 5th appeared normal at first but died after 4 weeks. He had a very slow growth and couldn’t use his hind legs properly.
----
Sire: sable b. 2003
Dam: sable b. 2002
Grandparents: sable
The dam has some sort of bite abnormality but I'm not sure what. People have described it as a minor misalignment/malocclusion of the teeth (jaws?). Her siblings are all normal. One of her siblings has a small stripe of white hairs under the chin.
The pedigree goes back a long way but is not complete. Closest unknown are the great grandparents of the sire. There may be depigmentation in his backgrnd since his breeder has such ferrets. Closest known depigmentation (on the dam’s side) is a great great grand dam who was a champagne mitt (and there are others like that further back). A great great grand sire was a full angora (sable).
---
The sire is said to have sired another NTD litter the same year with another jill, but that jill is some sort of light coloured silver with a big bib and big mitts and possibly other white markings.
/Marie
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*1999*
(I saw this litter IRL)
----
7 kits, 4 with head/brain and spinal defects, difficult prolonged delivery, the 4 affected were all stillborn and so was also one normal looking kit, the remaining 2 appeared normal but died after a couple of days, they were never able to get the jill to nurse them well
---
Sire: sable b. 1997
Dam: sable b. 1998
The sire was from a fur farm and had an all sable background. Grand parents and great grand parents of the dam are known and sable.
*2000*
(per owner‘s description + photos)
---
6 kits, 3 with hydrocephalus (euthanized), 1 missing parts of the brain (flat head) and protruding eyes (stillborn), 2 looked normal but were euthanized
---
Sire: sable b. 1999
Dam: sable b. 1999
Grandparents: sable
Closest unknown are the great grand parents of both sire and dam.
*2001*
(per owner's description + photos)
---
4 kits, all with spina bifida, 1 or 2 had a rather large exposed area on the spine, all were dead within 24 hours if I remember correctly
---
Sire: sable b. ?
Dam: sable b. 1998
I don’t know the background.
*2004*
( per owner's description)
----
5 kits, 4 with spina bifida died shortly after birth, the 5th appeared normal at first but died after 4 weeks. He had a very slow growth and couldn’t use his hind legs properly.
----
Sire: sable b. 2003
Dam: sable b. 2002
Grandparents: sable
The dam has some sort of bite abnormality but I'm not sure what. People have described it as a minor misalignment/malocclusion of the teeth (jaws?). Her siblings are all normal. One of her siblings has a small stripe of white hairs under the chin.
The pedigree goes back a long way but is not complete. Closest unknown are the great grandparents of the sire. There may be depigmentation in his backgrnd since his breeder has such ferrets. Closest known depigmentation (on the dam’s side) is a great great grand dam who was a champagne mitt (and there are others like that further back). A great great grand sire was a full angora (sable).
---
The sire is said to have sired another NTD litter the same year with another jill, but that jill is some sort of light coloured silver with a big bib and big mitts and possibly other white markings.
/Marie
To: Ferret-Genetics@yahoogroups.com
From: sukie@...
Date: Tue, 26 Jun 2007 12:03:41 -0400
Subject: Re: [Ferret-Genetics] Re: NTD and genetics?
It makes sense that it could occur, though rates would be different.
Do you have any data on those lines which can be shared, Marie?
Do the photos the poster included look like that sort of problem?
On Jun 26, 2007, at 7:38 AM, Marie Bartholdsson wrote:
>
>
> >From: sukie@...
> >Ah, except for ones with stub tails I have not run into NTD
> >descriptions in ferrets that I recall except associated with
> >depigmentation, though it would be worth checking the archives.
>
> I actually know of a few abnormal litters, presumably NTD, where
> both dam and sire were sables without any white markings. In some
> cases the background was at least 2 generations of sables but
> further than that I can't say. Those litters had multiple kits with
> exposed defects on the brain and spinal cord.
>
> Marie
>
>
>
> Hotmail to go? Get your Hotmail, news, sports and much more! Check
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>
>
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo. com/group/ ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/ index.html
http://www.miamiferret.org/fhc/
http://www.ferretcongress.org/
http://www.trifl.org/index. shtml
http://homepage.mac.com/sukie/ sukiesferretlink s.html
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