Wednesday, 28 November 2007, 10:48 GMT

'Supermouse' bred to beat cancer

Mice carrying a gene which appears to make them invulnerable to
cancer may hold the key to safer and more effective treatments for
humans.

The new breed, created with a more active "Par-4" gene, did not
develop tumours, and even lived longer, said the journal Cancer
Research.

University of Kentucky researchers said a human cancer treatment was
possible.

Cancer Research UK said that more research would be needed to prove
it didn't just work in mice.


We are thinking of this as a holistic approach that not only would
get rid of the tumour, but not harm the organism as a whole
Dr Vivek Rangnekar
University of Kentucky

Par-4 was originally discovered in the early 1990s working inside
human prostate cancers, and is believed to have a role in "programmed
cell death", the body's own system for rooting out and destroying
damaged or faulty cells.

The Kentucky team used an existing mouse breed known to be more
vulnerable to cancers to test whether Par-4 could be used to fight them.

They introduced the gene to mouse eggs, and it was active in both the
resulting pups - and their own offspring.

The mice with active Par-4 did not develop cancers, and lived
slightly longer than those without the gene.

Dr Vivek Rangnekar, who led the research, said that the gene offered
a potential way, unlike most other cancer treatments, of destroying
cancer cells without harming normal cells.

"When a cancer patient goes to the clinic, they undergo chemotherapy
or radiation and there are potential side effects associated with
these treatments.

"We are thinking of this as a holistic approach that not only would
get rid of the tumour, but not harm the organism as a whole."

Early stages

He said that much more research would be needed, however, before a
human treatment could be launched.

A spokesman for Cancer Research UK said: "Although at an early stage,
research like this allows us to understand more about the faulty
genes involved in cancer and throws open new avenues to explore for
cancer treatment.

"It's important to remember that this work has only been done using
genetically engineered mice, and more research is needed before we'll
know if it can be translated to humans."