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Ancient human genome sequence of an extinct Palaeo-Eskimo   Message List  
Reply Message #4004 of 4607 |
Thought you'd like this, Gisele:

The extracted history of Greenland/Kalaallisut by Razib Khan,
Science Blogs,
http://scienceblogs.com/gnxp/2010/02/the_extracted_history_of_green.php

Face of Ancient Human Drawn From Hair's DNA: Genome
paints picture of man from extinct Greenland culture, National
Geographic by Brian Handwerk,
http://news.nationalgeographic.com/news/2010/02/100210-ancient-human-dna-hair-sa\
qqaq-inuk/


"A 4,000-year-old hairball found frozen in Greenland has been
used to create the first ancient-human genome, says a new study
that paints a picture of a dark-eyed man with dry ear wax who
was prone to balding."

We report here the genome sequence of an ancient human. Obtained from
~4,000-year-old permafrost-preserved hair, the genome represents a male
individual from the first known culture to settle in Greenland. Sequenced to an
average depth of 20×, we recover 79% of the diploid genome, an amount close to
the practical limit of current sequencing technologies. We identify 353,151
high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not
been reported previously. We estimate raw read contamination to be no higher
than 0.8%. We use functional SNP assessment to assign possible phenotypic
characteristics of the individual that belonged to a culture whose location has
yielded only trace human remains. We compare the high-confidence SNPs to those
of contemporary populations to find the populations most closely related to the
individual. This provides evidence for a migration from Siberia into the New
World some 5,500 years ago, independent of that giving rise to the modern Native
Americans and Inuit.


Rasmussen, M., and many others, 2010, Ancient human genome
sequence of an extinct Palaeo-Eskimo. Nature. vol. 463, no. 7282,
pp. 757-762,
http://www.nature.com/nature/journal/v463/n7282/abs/nature08835.html


The Paleo-Eskimo Saqqaq and Independence I cultures, documented from
archaeological remains in Northern Canada and Greenland, represent the earliest
human expansion into the New World's northern extremes. However, their origin
and genetic relationship to later cultures are unknown. We sequenced a
mitochondrial genome from a Paleo-Eskimo human by using 3400-to 4500-year-old
frozen hair excavated from an early Greenlandic Saqqaq settlement. The sample is
distinct from modern Native Americans and Neo-Eskimos, falling within haplogroup
D2a1, a group previously observed among modern Aleuts and Siberian Sireniki
Yuit. This result suggests that the earliest migrants into the New World's
northern extremes derived from populations in the Bering Sea area and were not
directly related to Native Americans or the later Neo-Eskimos that replaced
them.



Paleo-Eskimo mtDNA Genome Reveals Matrilineal Discontinuity
in Greenland, Science,
http://www.sciencemag.org/cgi/content/abstract/320/5884/1787




Thu Feb 11, 2010 3:12 pm

preclovis250k
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Message #4004 of 4607 |
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Thought you'd like this, Gisele: The extracted history of Greenland/Kalaallisut by Razib Khan, Science Blogs,...
preclovis250k Offline Send Email Feb 11, 2010
3:13 pm

... [...] ... Yes, it is quite interesting to me - especially the ability to compare nuclear (recombining), NRY and mtDNA from the same 4000 yo individual. ...
ghorvat2001 Offline Send Email Feb 13, 2010
12:47 am

It also provided information,which suggests that the Saqqaq individual's ancestors may have migrated to Alaska from NE Siberia ca 5.5Ka,which is compatible...
Joan Butcher
bobandjoany Offline Send Email
Feb 13, 2010
8:29 pm
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