Search the web
Sign In
New User? Sign Up
J-mtDNA
? Already a member? Sign in to Yahoo!

Yahoo! Groups Tips

Did you know...
Want your group to be featured on the Yahoo! Groups website? Add a group photo to Flickr.

Best of Y! Groups

   Check them out and nominate your group.
Having problems with message search? Fill out this form to ensure your group is one of the first to be migrated to the new message search system.

Messages

  Messages Help
Advanced
Heteroplasmy in mtDNA or Testing Issues?   Message List  
Reply | Forward Message #856 of 1082 |
Re: Heteroplasmy in mtDNA or Testing Issues?

Heard from FamilytreeDNA regarding calling Heteroplasmy as follows:

"Thank you for your email. Heteroplasmies are sometimes difficult to identify as
they can be subjective. Your sample has a small heteroplasmy at position 16090.
It is small enough that Dr. Behar, our chief mtDNA scientist, felt it could not
confidently be identified as a heteroplasmy as opposed to noise in the sequence,
and so he did not report it. We report heteroplasmies if at least a third of the
mtDNA has each result, as that is enough to distinguish the heteroplasmy from
noise. In your sequence the C is much stronger than the T."

So, as I read it, FamilytreeDNA will call a heteroplasmy only if there is a
minimum of a 33%/67% mix.

Sally




Tue Jun 23, 2009 10:30 pm

kinbuch
Offline Offline
Send Email Send Email

Forward
Message #856 of 1082 |
Expand Messages Author Sort by Date

Previously, my Ancestry.com mtDNA testing revealed a heteroplasmic situation at 16090 in the HVR1 region and they typed me as 16090Y and in the haplogroup J. ...
kinbuch
Offline Send Email
Jun 11, 2009
5:59 pm

Sally: As I am sure you know, each cell has many mitochondria and each mitochondron has many copies of the DNA molecule. In a mtDNA test, a heteroplasmy is...
J. J. (Jim) Logan
jjlogan0
Offline Send Email
Jun 12, 2009
12:38 am

Heard from FamilytreeDNA regarding calling Heteroplasmy as follows: "Thank you for your email. Heteroplasmies are sometimes difficult to identify as they can...
kinbuch
Offline Send Email
Jun 23, 2009
10:30 pm
Advanced

Copyright © 2009 Yahoo! Inc. All rights reserved.
Privacy Policy - Terms of Service - Guidelines - Help