Time:                           2:00pm to 5:00pm, Saturday, May 17, 2008

Location:          Finisar Corporation, 36 Jonspin Road, Wilmington, MA 01887

Topic:                          Biomedical Imaging

 

2:00pm-2:30pm Networking Time

2:30pm-2:45pm Introduction

2:45pm-3:45pm Intravascular Imaging with Optical Coherence Tomography (OCT)

Dr. Joseph M. Schmitt, Chief Technical Officer, LightLab Imaging

Abstract: The introduction of optical coherence tomography (OCT) into the marketplace for ophthalmic imaging marks the successful transfer of a new imaging technology from the research bench to the patient's bedside.  This talk will trace the development of an important new emerging application of OCT:  imaging inside the coronary arteries.  The talk will highlight technical advances in swept-source laser design made by LightLab Imaging, a start-up company founded to commercialize technology developed originally at the Massachusetts Institute of Technology.   Results from clinical studies will be presented in which OCT is used for guidance of stent implantation and other coronary interventions.  

Dr. Schmitt received the B.S. degree in biomedical engineering/pre-medicine from Case Western Reserve University in 1981 and the M.S. and Ph.D. degrees in electrical engineering from Stanford University in 1983 and 1986, respectively.  After serving as Biomedical Engineering Coordinator for a non-profit health-care foundation in China for two years, he worked at the National Institutes of Health in Bethesda, MD, as a Senior Staff Fellow.  Dr. Schmitt later joined the Hong Kong University of Science and Technology (HKUST) as Associate Professor in the Department of Electrical Engineering where he also served as the Co-Director of the Center for Medical Diagnostic Technology.  He left HKUST to develop non-invasive optical technologies for patient monitoring at Nellcor Puritan- Bennett in Pleasanton, CA.  His present position, held since 2000, is Chief Technology Officer of LightLab Imaging, a company focused on commercializing medical applications of optical coherence tomography

 

3:45pm-4:00pm Break

4:00pm-5:00pm New Techniques in Biological Imaging

Prof. Jerome Mertz, Boston University, Biomedical Engineering Department

Light microscopy has undergone a renaissance in recent years. In 1990, Webb and Denk demonstrated the possibility of generating two-photon excited fluorescence (TPEF) to produce biological images with sub-micron resolution in thick tissue. Since then, TPEF microscopy has gained widespread interest, particularly in neurobiology and developmental biology. Nonlinear contrast mechanisms may also be based on scattering instead of absorption. For example, second-harmonic generation (SHG) microscopy, which actually predates TPEF microscopy, is gaining renewed attention as a unique tool for the visualization of cell membrane potential.

Alternatively, fluorescence microscopy techniques based on structured or speckle illumination have also gained considerable interest. These technique provide out-of-focus background rejection similar to a confocal microscope, but without the use of a pinhole. 

I will review the principles of these new microscopy techniques and describe some recent developments in my laboratory. Most of these developments have been applied specifically to neuronal imaging in-vitro or in-vivo.

Dr. Jerome Mertz received an AB in physics from Princeton University in 1984, and a PhD in quantum optics from UC Santa Barbara and the University of Paris VI in 1991. Following postdoctoral studies at the University of Konstanz, Germany (Jürgen Mlynek group) and at Cornell University (Watt Webb group), he obtained a lecturer position at the Ecole Supérieure de Physique et de Chimie Industrielle in Paris, where he became a CNRS research director. He is currently an associate professor of Biomedical Engineering at Boston University. His interests are in the development and applications of novel optical microscopy techniques for biological imaging. Areas of research include two-photon microscopy, second-harmonic generation microscopy, phase-contrast microscopy, speckle illumination microscopy, optical coherence tomography, etc.

 

Contact: Yong Qiao (978) 201-1980, Frank Fan (978) 204-4980, Jin Li (978) 996-8058  

Organizers: Jin Li, Yong Qiao, Qingwu Wang, Xueyan Zheng, Frank Fan, and Yi Qian

For more information, please visit the following sites

NECINA Optics SIG : http://groups.yahoo.com/group/NECINA_SIG_Optics/

NECINA: http://www.necina.org/