Isabelle

Have you seen this article? What do you think? Please post it on the
site. Has anybody else heard about this treatment???!!!

Marie-France
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Autologous transplantation of granulocyte colony-stimulating
factor-mobilised peripheral blood mononuclear cells improves critical
limb ischaemia in diabetes.
Huang, P, Li, S, Han, M, Xiao, Z, Yang, R, Han, ZC.
Diabetes Care 2005;28:2155-2160.

28 DM patients with critical limb ischaemia (CLI) were randomised to
transplant or control. The transplant group were given 5 days sc
recombinant human G-CSF (600 microg/d) and their PBMNCs were collected
and transplanted by multiple im injections into ischaemic limbs. After 3
m, lower limb pain and ulcers were significantly improved in transplant
patients. Laser doppler blood perfusion of lower limbs increased from
0.5 +/- 0.21 to 0.63 +/- 0.25 (P<0.001). 14/18 (77.8%) ulcers completely
healed compared to 7/18 (38.9%) in controls (P+0.016). No adverse
effects observed and no amputations in transplant group v 5 amputations
in controls (P=0.007). Angiographic scores were also significantly
improved v controls (P+0.003). These are very encouraging results,
indicating that this process is simple, safe and effective.


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