Dear Oleg
at my opinion, we should have to use monotherapy fot treatment MRSA
infection. I, unfortunally, can't link you to any any articles about
it, but in my expirience was number of patients ondergoing with Rif
alone. after less when 1 week MRSA became resistent to treatment
best regards
timur V. Gusov

>
> Dear Colleagues,
> Maybe somebody of you could advise me:
> When we treat MRSA infection, many authors recommend to use 2
> antibiotics simultaneously (like Rif+Fusid or Rif+Ciprofl or
> Clind+Doxycycl, etc.). For example - M.Young in his
> article "Managing
> of infection in the diabetic foot" (DF Journal, 2007, Vol.10, No 1,
> p.10) describes such practice in his hospital.
> In a very good (IMHO) article about Rifampicin Steffee et al
> (Clinical
> use of rifampicin during routine reporting of rifampicin
> susceptibilities: a lesson in selective reporting of antimicrobial
> susceptibility data. / J. Antimicrob. Chemotherapy, Oct 1997; v. 40,
> p. 595 - 598.
> http://jac.oxfordjournals.org/cgi/reprint/40/4/595 )
> write about high risk of resistance developement after Rif
> monotherapy.
> I've read the same about fusidic acid.
> As I understand, Vancomicin and Linezolid have lower potential for
> resistance.
> So my question is:
> If we use not Vanco or Linez but cheeper drugs (Rif, Fusid, Cipro,
> Doxycycl, Clind) and have culture results with antibiotic
> succeptibility data of this MRSA isolate - may we use monotherapy?
> Are there any publications / guidelines about number of antibiotics
> necessary in such cases?
> SY,
> Oleg.
>