Dear members of this list,

I would appreciate if anyone help me in order to get two articles
which is very helpfull for me in order to improve my work with
maphazoline.
The references are:

1) Synthesis and identification of the primary degradation product in
a
commercial ophthalmic formulation using NMR, MS, and a
stability-indicating HPLC method for antazoline and naphazoline.
J Pharm Sci. 1995 Apr;84(4):502-7.

2) High-performance liquid chromatographic stability-indicating assay
for naphazoline and tetrahydrozoline in ophthalmic preparations.
Thanks in advance for the help,
J Pharm Sci. 1983 Nov;72(11):1347-9. Links

Thanks a lot in advance,

Diego

11th December 2006

Dear colleagues,

I would like a copy of the following article if any of you have it in
your research library:

Parpinello, Giuseppina Paola; Versari, Andrea.
A simple high-performance liquid chromatography method for the analysis
of glucose, glycerol, and methanol in a bioprocess.
Journal of Chromatographic Science  (2000),  38(6),  259-265.

Thank you in advance for your help.

Kind regards,

Tony Herlt

Research School of Chemistry
Building 35, Australian National University campus
Science Road, Acton
Canberra, ACT 2601
Australia

phone:  +61 (0)2 6125 9765
mobile: 0404 823 159
fax:  +61 (0)2 6125 0750
e-mail: herlt@...
----------------------

Hi,





we are currently testing a batch of alpha terpineole (FCC). The
requirement for the assay is: not less than 96.0% (sum of alpha-,
(E)-beta-, (Z)-beta-, gamma-, terpinen-4-ol, and terpinen-1-ol isomers)
using a polar column. I am now wondering, how I can find out, which
peaks are allowed and which are not. Where can I get an exemplary gas
chromatogram with the peaks of all isomers or do I have do buy all
possible isomers?



Would be very grateful for any help. Our supplier Fluka wasn’t of any
help. They only told me, that their GC data are their proprietary



Best regards



Thomas Vater




--
No virus found in this outgoing message.
Checked by AVG Free Edition.
Version: 7.1.409 / Virus Database: 268.15.3/562 - Release Date:
01.12.2006



[Non-text portions of this message have been removed]

Anyone have a good method for caffeine (or other markers of human
sewage) in river water?  Preferrably SPE HPLC but GCMS could work
also.  The more detailed the better.

Thanks in advance.

Dear colleagues,
   I'm needing some help again! I need 2 articles that I don't have access.   Can
somebody send them to me?



1:  Lapolla A, Flamini R, Dalla Vedova A, Senesi A, Reitano R, Fedele D, Basso 
E, Seraglia R, Traldi P.    Glyoxal and methylglyoxal levels in diabetic
patients: quantitative  determination by a new GC/MS method.  Clin Chem Lab Med.
2003 Sep;41(9):1166-73.     2:  Lapolla A, Flamini R, Tonus T, Fedele D, Senesi
A, Reitano R, Marotta E,  Pace G, Seraglia R, Traldi P.    An effective
derivatization method for quantitative determination of glyoxal  and
methylglyoxal in plasma samples by gas chromatography/mass spectrometry.  Rapid
Commun Mass Spectrom. 2003;17(8):876-8. No abstract available.     Thank you a
lot.

Guilherme



--------------------------------------------------------------
Guilherme Vannucchi Portari
Farmacêutico-Bioquímico
Técnico da Disciplina de Bromatologia do Curso de
Nutrição e Metabolismo - USP Ribeirão Preto
F: 55 (16) 3602-4629
------------------------------------------------------------------------------
Technician of Food Science Laboratory
Nutrition and Metabolism Faculty
University of Sao Paulo - Brazil
---------------------------------------------------------------
E-mail: gv_portari@...
---------------------------------------------------------------










---------------------------------
  Novidade no Yahoo! Mail: receba alertas de novas mensagens no seu celular.
Registre seu aparelho agora!

[Non-text portions of this message have been removed]

Dear members of this forum,

Thanks for all owing to many members gave the information I need in order to
finish my work.
Thanks as always again,

Diego


----- Original Message -----
From: "Walter Holberg" <wholberg@...>
To: <tequila2@...>; <chrom-L@yahoogroups.com>
Sent: Thursday, June 22, 2006 8:50 PM
Subject: Re: [chrom-L] About technical specifications


> These links will have the information you need.
>
> 600E pump:
>
http://www.waters.com/WatersDivision/SiteSearch/AppLibDetails.asp?LibNum=720
000751EN
>
> 490E detector:
>
http://www.waters.com/WATERSDIVISION/SiteSearch/AppLibDetails.ASP?LIBNUM=940
409
>
> The manufacturer's website has everything you need.  If you are unable to
> download the product .pdf files, call Waters and they will email them to
> you.
>
>
>
>
> ----- Original Message -----
> From: <tequila2@...>
> To: <chrom-L@yahoogroups.com>
> Sent: Thursday, June 22, 2006 10:41 AM
> Subject: [chrom-L] About technical specifications
>
>
> > Dear members of this forum,
> >
> > I need your help in order to get information about technical
> > specifications of two modeules of a Waters HPLC, these are: Pump 600 E
> > and Detector 490 E. I would like to get information as: drift, noise,
> > lamp type, volume cell, path length. maximum pressure, flow range and
> > so on.
> > Thanks in advance for your help,
> >
> > Diego
> >
> >
> >
> > ______________________________________________
> > Searchable message archive :
> > http://groups.yahoo.com/group/chrom-l/messages
> >
> > Sites of interest :
> > http://groups.yahoo.com/group/chrom-l/links
> >
> > To unsubscribe send email to :
> > mailto:chrom-L-unsubscribe@yahoogroups.com
> > ______________________________________________
> >
> >
> > Yahoo! Groups Links
> >
> >
> >
> >
> >
> >
> >
>
>
>
>
>
>
>
> ______________________________________________
> Searchable message archive :
> http://groups.yahoo.com/group/chrom-l/messages
>
> Sites of interest :
> http://groups.yahoo.com/group/chrom-l/links
>
> To unsubscribe send email to :
> mailto:chrom-L-unsubscribe@yahoogroups.com
> ______________________________________________
>
>
> Yahoo! Groups Links
>
>
>
>
>
>
>
>
> --
> No virus found in this incoming message.
> Checked by AVG Free Edition.
> Version: 7.1.394 / Virus Database: 268.10.1/391 - Release Date: 18/07/06
>
>

I want to find k and alpha for poly(ethylen)glycole adipate in chlorophorm to
make some GPC measurements.
   Can somebody help me?
   A.T


---------------------------------
Yahoo! Messenger with Voice. Make PC-to-Phone Calls to the US (and 30+
countries) for 2¢/min or less.

[Non-text portions of this message have been removed]

At 05:14 AM 7/4/2006, Vivek Upadhyay wrote:

>Dear Friends,
>
>  I am using an old Varian 3400 GC (with FID detector; there is no slip
injector). I am injecting 1 ul of sample (in pentane/hexane). It is giving me a
very big solvent peak. For Pentane it starts from 2 min upto 5.5 min and takes
appx. 5 min before the baseline stabilises. Can anyone suggest how to improve
upon this ?
>
>  Thanks in advance,
>
>  Vivek

You didn't say, but I'll assume you're using a common capillary column.

Check your split ratio.  It sounds like you're running a splitless injection, so
that all of the solvent is put on the column.  1 uL of solvent will fill a 30m x
0.25mm capillary column, and then some.  The split ratio is usually 50/1 or
100/1, so that only 1-2% of the injection actually goes onto the column.  Your
dead time of 2 minutes sounds about right, and the plug of solvent would take
2-3 minutes after that to clear the column.

There should be a split vent on the front of the instrument.  Check that flow,
assume that the column flow is 1uL/min, and calculate the ratio.  Check the
manual for the operation of the injection system.  Our 5890 has the split always
on, but turns it off for a user-defined time when an injection is made.  A time
of 0.01 minutes is for split injections, while we use 0.5 minutes for splitless.

David


David Bostwick
Bioanalytical Mass Spectrometry Facility
School of Chemistry and Biochemistry
Georgia Institute of Technology
315 Ferst Drive
Atlanta. GA 30332-0363
Phone: 404-385-4250
FAX: 404-894-4061

Dear Members,

I wanted to fill SS column with C 18 material.Does any one can help me as
how to fill the column or give me a clean procudure guidelines,The column
Length 30 cm & id is 60mm ( semi preprative Type ). Please guide me as how
to fill adsorbent material inside the column.

regards

Rajesh

----- Original Message -----
From: "Rajesh Galgalikar" <rajesh@...>
To: <tequila2@...>
Sent: Thursday, June 22, 2006 9:40 PM
Subject: Re: [chrom-L] About technical specifications


> Dear Members,
>
> I wanted to fill SS column with C 18 material.Does any one can help me as
> how to fill the column or give me a clean procudure guidelines,The column
> Length 30 cm & id is 60mm ( semi preprative Type ). Please guide me as how
> to fill adsorbent material inside the column.
>
> regards
>
> Rajesh
>
> ----- Original Message -----
> From: <tequila2@...>
> To: <chrom-L@yahoogroups.com>
> Sent: Thursday, June 22, 2006 8:11 PM
> Subject: [chrom-L] About technical specifications
>
>
>> Dear members of this forum,
>>
>> I need your help in order to get information about technical
>> specifications of two modeules of a Waters HPLC, these are: Pump 600 E
>> and Detector 490 E. I would like to get information as: drift, noise,
>> lamp type, volume cell, path length. maximum pressure, flow range and so
>> on. Thanks in advance for your help, Diego
>>
>>
>> ______________________________________________
>> Searchable message archive :
>> http://groups.yahoo.com/group/chrom-l/messages
>>
>> Sites of interest :
>> http://groups.yahoo.com/group/chrom-l/links
>>
>> To unsubscribe send email to :
>> mailto:chrom-L-unsubscribe@yahoogroups.com
>> ______________________________________________
>>
>>
>> Yahoo! Groups Links
>>
>>
>>
>>
>>
>>

If your samples are soluble in it, you can try carbon disulfide, CS2.
The FID is almost 'blind' to this solvent, keeping a low steady
baseline.



You will need to be tolerant of it's fragrance.

The information contained in this e-mail message and any attachments may
be confidential. It is intended only for the use of the individual or
entities named above. If the reader of this message is not the intended
recipient, you are hereby notified that any dissemination, distribution
or copying of this communication is strictly prohibited.  If you have
received this communication in error, please notify us immediately by
e-mail at the originating address.

Peter Lazarski
National Grid USA
Lab. & Testing Svcs., Bldg. 1
7437 Henry Clay Blvd.
Liverpool, NY 13088
(315)460-2114

________________________________

From: chrom-L@yahoogroups.com [mailto:chrom-L@yahoogroups.com] On Behalf
Of Vivek Upadhyay
Sent: Tuesday, July 04, 2006 5:14 AM
To: chrom-L@yahoogroups.com
Subject: [chrom-L] Solvent peak




Dear Friends,

I am using an old Varian 3400 GC (with FID detector; there is no slip
injector). I am injecting 1 ul of sample (in pentane/hexane). It is
giving me a very big solvent peak. For Pentane it starts from 2 min upto
5.5 min and takes appx. 5 min before the baseline stabilises. Can anyone
suggest how to improve upon this ?

Thanks in advance,

Vivek


---------------------------------
Want to be your own boss? Learn how on Yahoo! Small Business.

[Non-text portions of this message have been removed]




**** For your information: Granite State Electric, Massachusetts Electric,
Nantucket Electric, Narragansett Electric, and Niagara Mohawk are each doing
business under the name National Grid. ****

This e-mail and any files transmitted with it, are confidential to National Grid
and are intended solely for the use of the individual or entity to whom they are
addressed.  If you have received this e-mail in error, please reply to this
message and let the sender know.


[Non-text portions of this message have been removed]

Dear Friends,

   I am using an old Varian 3400 GC (with FID detector; there is no slip
injector). I am injecting 1 ul of sample (in pentane/hexane). It is giving me a
very big solvent peak. For Pentane it starts from 2 min upto 5.5 min and takes
appx. 5 min before the baseline stabilises. Can anyone suggest how to improve
upon this ?

   Thanks in advance,

   Vivek


---------------------------------
Want to be your own boss? Learn how on  Yahoo! Small Business.

[Non-text portions of this message have been removed]

These links will have the information you need.

600E pump:
http://www.waters.com/WatersDivision/SiteSearch/AppLibDetails.asp?LibNum=7200007\
51EN

490E detector:
http://www.waters.com/WATERSDIVISION/SiteSearch/AppLibDetails.ASP?LIBNUM=940409

The manufacturer's website has everything you need.  If you are unable to
download the product .pdf files, call Waters and they will email them to
you.




----- Original Message -----
From: <tequila2@...>
To: <chrom-L@yahoogroups.com>
Sent: Thursday, June 22, 2006 10:41 AM
Subject: [chrom-L] About technical specifications


> Dear members of this forum,
>
> I need your help in order to get information about technical
> specifications of two modeules of a Waters HPLC, these are: Pump 600 E
> and Detector 490 E. I would like to get information as: drift, noise,
> lamp type, volume cell, path length. maximum pressure, flow range and
> so on.
> Thanks in advance for your help,
>
> Diego
>
>
>
> ______________________________________________
> Searchable message archive :
> http://groups.yahoo.com/group/chrom-l/messages
>
> Sites of interest :
> http://groups.yahoo.com/group/chrom-l/links
>
> To unsubscribe send email to :
> mailto:chrom-L-unsubscribe@yahoogroups.com
> ______________________________________________
>
>
> Yahoo! Groups Links
>
>
>
>
>
>
>

I am trying to analyze zoledronate in serum
by derivatizing it to its ethyl ester and then
analyzing by GC-MS,however,the internal standard used
in the article that is the basis of my technique they
are using a deuterated version of zoledronate as the
internal standard. I am unable to obtain such a
compound, does anyone have any suggestions for an
alternate standard to use, or another method for the
determination of the concentration of bisphosphonates
in serum.

Dear members of this forum,

I need your help in order to get information about technical
specifications of two modeules of a Waters HPLC, these are: Pump 600 E
and Detector 490 E. I would like to get information as: drift, noise,
lamp type, volume cell, path length. maximum pressure, flow range and
so on.
Thanks in advance for your help,

Diego

Production Chemist - Torrance, CA

I am assisting to recruit Production Chemists (at all levels including
management) for a biochemical company located in Torrance, CA.  Below are
the job descriptions, requirements, company information and application
information for your review.

JOB FUNCTION:
The job function of the Chemist is to be a part of a production team for the
manufacturing of peptides including synthesis, cleavage, purification and
in-process analysis. The Chemist III can carry out projects independently
with minimal supervision and deputize for the immediate supervisor.

ESSENTIAL FUNCTIONS:
Independently perform peptide synthesis, cleavage and purification.  Run the
necessary in-process controls.  Comply with SOP's and cGMP in all aspects of
his/her work.  Keep records of all aspects of work performed.  The Chemist
II and III will have the additional function of proposing technical and
chemical improvements in manufacturing.

ADDITIONAL RESPONSIBILITIES:
Make safe, efficient and conscious use of instruments, raw materials and
other resources provided.  The Chemists III also deputizes for immediate
supervisor and coordinate tasks within the group and contribute to/work on
multiple projects in parallel.

EDUCATIONAL REQUIREMENTS:
Bachelors' degree in Organic Chemistry, Biochemistry or equivalent. Good
English skills both written and oral.

EXPERIENCE & QUALIFICATION:
Chemist I:
2-3 years hands-on experience in a chemistry laboratory either during course
work or in industry. Experience in a cGMP environment desirable or
experience in an industrial chemistry laboratory.

Chemist II:
2-5 years of successful career experience as a peptide production chemist in
a GMP environment.

Chemist III:
At least 5 years of successful career experience as a peptide production
chemist.
Proficient with GMP requirements.

SKILLS:
Chemist I:
Understanding of basic chemistry. Industrial experience desirable.
Regulatory experience desirable. (cGMP) Computer literate. Good
communication skills

Chemist II and III:
Working knowledge of peptide chemistry. Broad experience in all aspects of
peptide manufacturing. Familiarity with GMP requirements. Efficient and safe
laboratory practice. Computer literate. Good communication skills.
Dedicated, loyal and well organized. Ability to train new staff in
laboratory procedures.
Knowledgeable with production equipment.

SUPERVISION:
A Chemist III will provide interim supervision and training of new employees
on an as-needed basis.

COMPANY:
They are an international, technology-based company specializing in the
production of innovative biochemical and pharmaceutical compounds. This
position is within the division that has scientific know-how in peptide
conjugation, antibody production (against peptides and proteins) for
immunoassay, immunohistochemistry and immunocytochemistry, kit formulation
and iodination of peptides. The company employs 530 motivated and qualified
people worldwide.

If you are interested in pursuing one of these opportunities, please forward
all of the following to resumes@...:

-resume with brief cover note addressing your qualifications relating to the
position requirements.
-salary requirement. If you are open or flexible in terms of compensation,
please provide details (base/bonus/incentives) on your current or most
recent compensation.
-relocation considerations. (i.e. home to sell, etc) or confirmation that
Torrance is commutable for you. This company does have a relocation program
and will relocate candidates from anywhere within the United States.
-work authorization. (i.e. US citizen, H1B, etc). Although not preferred,
this company will transfer an H1B visa for an exceptionally well qualified
candidate.

Please note, all of the requested information must be provided in order to
properly evaluate your candidacy.

--
No virus found in this outgoing message.
Checked by AVG Free Edition.
Version: 7.1.394 / Virus Database: 268.8.1/355 - Release Date: 6/2/2006



[Non-text portions of this message have been removed]

Hi,
   I'm PHD student and I need the fragmentation scheme of polystyrene.
   Please help me



---------------------------------
Blab-away for as little as 1¢/min. Make  PC-to-Phone Calls using Yahoo!
Messenger with Voice.

[Non-text portions of this message have been removed]

hi friends

any one help me

How to Develop GC Impurity pfofile method for Drug products in
Formulations ? can you give one compound example?
what is the Role of RRF on Impurity profile Method ?
thank for all

Couldn't this be done using 2,4-dinitrophenylhydrazine derivatization as is
done with aldehydes?

On a related note... Does anyone know of any methods where amines are
derivatized to perform an analysis?
For example, I have a primary amine which I'm trying to run on a C18 column
with a low pH buffer.  Because the amine is protonated at this low pH, I get
poor retention and selectivity.  Could I derivatize with ninhydrin and
determine the amine-ninhydrin derivative at higher wavelength (540nm)?
Could the same be done using p-dimethylaminobenzaldehyde with indoles?

Anyone have thoughts/experience on this?

Thanks,

Moecat

----- Original Message -----
From: "Lasmiyati" <mamik_lasmiyati@...>
To: <chrom-l@yahoogroups.com>
Sent: Tuesday, May 23, 2006 9:51 AM
Subject: [chrom-L] Glucose analysis by HPLC


> Dear chrom-l members,
>
>  I need some information how to identification glucose in strach solution
> by HPLC, such as suitable eluent, column, and other else, may be some
> journals about it.
>  Thanks for help.
>
>  Regards,
>
>  Lasmiyati

hi friends

any one can help How to Develop Gc Impurity profile method for Drug
producuts in Formulations? can you give any example? can you explain
what is the role of RRF on Impurity profile Method?
thanks for every one

Hi all,

I recently graduated from the University of Connecticut with a BS in
Chemistry. I have a very strong analytical background with over 3
years experiences in developing methods using HPLC coupled to ICPMS. I
am also acquainted with the basics pertaining to other analytical
techniques, including Size Exclusion Chromatography (SEC), Graphite
Furnace Atomic Absorption Spectroscopy (GF-AAS) and Gas Chromatography
(GC) and many others.

That'd be great if any of you know/need to hire an analytical chemist
in your companies and contact me through my e-mail below. Thank you
very much!!

Lee Lee Chung
lee.chung@...

Anyone know of a good resource for Biochemical Genetics Methods (Medical
Labs)?

thank you

Dear chrom-l members,

   I need some information how to identification glucose in strach solution by
HPLC, such as suitable eluent, column, and other else, may be some journals
about it.
   Thanks for help.

   Regards,

   Lasmiyati



---------------------------------
New Yahoo! Messenger with Voice. Call regular phones from your PC and save big.

[Non-text portions of this message have been removed]

Dear members of this forum,

I am working with mebeverine in pharmaceutical tablets and I am very
interesting in getting your work in raw materials and tablets and it
was very difficult to get this work from internet.
The specific reference is:
A new RP-HPLC method for analysis of mebeverine hydrochloride in raw
materials and tablets. Arayne MS, Sultana N, Siddiqui FA. Pak J Pharm
Sci. 2005 Apr;18(2):11-4.
I would appreciate any help in order to get this work.
Thanks in advance for your help.

Diego

 
I am receiving mails from this group in digest form. I had received Digest 837
and above which means I had missed 836 digests with huge information. Can any
body send these digest to me in ZIP file because it is not possible for me to
access each mail from archive due to low resources.

[Non-text portions of this message have been removed]

Dear users,

I've found that many people commonly backflush C18 and C8 columns in
order to clean them.  I've also heard from some that recommend avoiding
this practice.  Can anyone give me the correct answer?  I guess it may
vary from one column manufacturer to another but I would like to know
some reasons why backflushing columns can adversely affect columns.

-Bao

Hi friends,

I need your opinion about the LC/MS/MS of Applied Biosystems API 3200
and Thermofinnigan (Thermo electron corporation). Could you pls. give
your valuable inputs?. Our aim of buying this instrument is for
routine analysis purposes of Antibiotic residues & pesticides.

Thanks
anish

Dear Sir/Madam,
I am using GC/ECD, Chrompack,CP9001 to analayzing THMs in water
samples.
My sample preparation method is extraction.
My column is "CP-SIL 8CB, CAT.NO.7482, 50m*0.25mm"
My method is :
Column limit ......... 300
Initial Temp. ......... 50
Final Temp. .......... 250
Oven rise ............. 40 oC/min
Time initial ........... 15 min
Time final ............. 10 min
Det. Temp. ........... 300oC
Inj. Temp. ............. 280 oC

Injection mode is split/splitless.

When I want to do my analysis I faced to some problems! I could not
see any peack of THMs in my Chromatogram and it just shows the
solvent's peack (Methanol). (Actually i am sure about the nature of
the solution which I inject. It is exactly the solution of THMs in
Methanol.

Another problem is when i want to open a data chromatogram from saved
ones, I first open method and then open the data in the method, The
method is ECD, but the bar above the windows opened shows: Channel A,
FId.
I opened the "Acquisition Parameter" and there is channel B marked,
sample frequency shows 1.111Hz,Run time: 30 min. Why does it shows
Channel A FID? as the method is for ECD.

Would you please help me for both problems?
I would be very grateful if my request meets your favorable
consideration.
Hope to hear from you soon.
Yours faithfully,
Semiramis Badri

You probably can find the information you need by searching the archives
of the listserv below -

http://listserv.syr.edu/archives/plasmachem-l.html

-----Original Message-----
From: chrom-L@yahoogroups.com [mailto:chrom-L@yahoogroups.com] On Behalf
Of rajneeshanand
Sent: Tuesday, April 04, 2006 8:01 AM
To: chrom-L@yahoogroups.com
Subject: [chrom-L] ICP-MS

Hello All,

We are in the process of purchasing an ICP-MS. But I am confused by
all the technologies available in the market. Please suggest which
technology is better Dynamic Reaction Cell or Collision cell. Please
suggest.

Rajneesh







______________________________________________
Searchable message archive :
http://groups.yahoo.com/group/chrom-l/messages

Sites of interest :
http://groups.yahoo.com/group/chrom-l/links

To unsubscribe send email to :
mailto:chrom-L-unsubscribe@yahoogroups.com
______________________________________________


Yahoo! Groups Links











**** For your information: Granite State Electric, Massachusetts Electric,
Nantucket Electric, Narragansett Electric, and Niagara Mohawk are each doing
business under the name National Grid. ****

This e-mail and any files transmitted with it, are confidential to National Grid
and are intended solely for the use of the individual or entity to whom they are
addressed.  If you have received this e-mail in error, please reply to this
message and let the sender know.

A size separation before the C-18 column will pull out the polymer and if
backflushed to an analytical C-18 column you separation may be very fast.
This is a common sample cleanup procedure and is featured be several
manufactures. Cohesive Technologies is one supplier who suggest this
approach to clean up messy plasma samples pulling the drug away from the
proteins based on size.
Bill Suits
ChemPharma www.chempharma.net
MARM www.marmacs.org
NJACS www.njacs.org
908-875-9069

----- Original Message -----
From: <chrom-L@yahoogroups.com>
To: <chrom-L@yahoogroups.com>
Sent: Friday, April 07, 2006 8:36 AM
Subject: [chrom-L] Digest Number 844


> There are 5 messages in this issue.
>
> Topics in this digest:
>
>       1. [Job Advert] DMPK Scientist - Vista, CA
>            From: <resumes@...>
>       2. Explanation Needed !
>            From: "chang" <chang@...>
>       3. Method Development issues for Kollidon
>            From: "baovmai" <sandiegokidd2000@...>
>       4. Problems in method development for analytical HPLC analysis
>            From: "baovmai" <sandiegokidd2000@...>
>       5. ICP-MS
>            From: "rajneeshanand" <rajneeshanand@...>
>
>
> ________________________________________________________________________
> ________________________________________________________________________
>
> Message: 1
>    Date: Wed, 29 Mar 2006 09:15:37 -0700
>    From: <resumes@...>
> Subject: [Job Advert] DMPK Scientist - Vista, CA
>
> DMPK Scientist - Vista, CA
>
> I am assisting to recruit a motivated individual to coordinate all DMPK
> efforts (including analysis of In-Vitro and In-Vivo DMPK samples using an
> API 3200 Q-trap) and supporting chemical process optimization for a great
> company in Vista, CA.
>
> Here is more information:
>
> Requires:
> Advanced degree in science, 4+ years relevant industrial, academic, or
> combined experience. You must be committed to work effectively in a small
> company, team-based environment.  Excellent communication and laboratory
> organizational skills are essential. Knowledge of in-vitro CYP450
metabolism
> assays, metabolite identification, in-vivo pharmacokinetic analyses, in
vivo
> procedures, LC/MS/MS operation and maintenance, and small molecule
> purification is highly desirable.
>
> Apply:
> If you are interested in this position, please forward your Word formatted
> resume, cover note and salary requirement to
> resumes@.... Please include the specific position to
> which you are applying in the subject line of your email. This will ensure
> your resume is routed to the correct recruiter as quickly as possible.
>
> Thank you for your time - have a great day!
> --
> No virus found in this outgoing message.
> Checked by AVG Free Edition.
> Version: 7.1.385 / Virus Database: 268.3.3/295 - Release Date: 3/28/2006
>
>
> [Non-text portions of this message have been removed]
>
>
>
>
>
>
> ________________________________________________________________________
> ________________________________________________________________________
>
> Message: 2
>    Date: Wed, 29 Mar 2006 21:49:44 -0300
>    From: "chang" <chang@...>
> Subject: Explanation Needed !
>
>     Can someone tell me if the affirmation is correct ?
>
> "ESI and MALDI are not techniques that volatilize polar compounds"
>
>     These are techniques of ionization, can they be prefered towards a
polar or apolar compound ?
>     Thanks for the replies......
>
>
> [Non-text portions of this message have been removed]
>
>
>
>
>
>
> ________________________________________________________________________
> ________________________________________________________________________
>
> Message: 3
>    Date: Fri, 31 Mar 2006 18:45:40 -0000
>    From: "baovmai" <sandiegokidd2000@...>
> Subject: Method Development issues for Kollidon
>
> Dear group,
>
> I need to analyze my drug product which contains Kollidon, a polymer,
> by HPLC/MS.  Currently, I am using a C18 column and employing a
> gradient for elution but the Kollidon is creating a large rolling peak
> eluting just before my API and is masking some of my degradation
> products.  I am using a mobile phase of water and acetonitrile, both
> with 0.01% TFA.  The way I see things, I either need to sharpen up this
> peak drastically or perform a pre injection clean up of my sample such
> as using SPE.  I'd like to get thoughts and suggestions from members of
> this group on how to approach this issue.
>
> Thanks in advance,
> Bao
>
>
>
>
>
>
>
>
> ________________________________________________________________________
> ________________________________________________________________________
>
> Message: 4
>    Date: Wed, 05 Apr 2006 04:49:39 -0000
>    From: "baovmai" <sandiegokidd2000@...>
> Subject: Problems in method development for analytical HPLC analysis
>
> Dear Members,
>
> I am performing method development for analytical HPLC analysis of a
> drug product solution that contains a polymer called Kollidon.  I am
> utilizing UV detection but my dilemma is that the Kollidon is highly UV
> absorbing; even more so than my API.  It is causing a large rolling
> peak that is masking many of my degradation products.  My thought was
> to initially sharpen the peak where it wouldn't interefere with any of
> my product peaks.  I am currently employing a gradient elution and have
> tried a number of different C18 columns including polar embedded
> groups, 150 mm and 250 mm length columns, and 3um and 5um size particle
> size columns.  I haven't had any luck with this approach and am now
> leaning toward performing an SPE clean up of the sample prior to
> injection.  I do not have much experience in the area of pre-injection
> sample prep and I would welcome any thoughts or suggestions from
> members in the group.
>
> -Bao
>
>
>
>
>
>
>
>
> ________________________________________________________________________
> ________________________________________________________________________
>
> Message: 5
>    Date: Tue, 04 Apr 2006 12:01:22 -0000
>    From: "rajneeshanand" <rajneeshanand@...>
> Subject: ICP-MS
>
> Hello All,
>
> We are in the process of purchasing an ICP-MS. But I am confused by
> all the technologies available in the market. Please suggest which
> technology is better Dynamic Reaction Cell or Collision cell. Please
> suggest.
>
> Rajneesh
>
>
>
>
>
>
>
> ________________________________________________________________________
> ________________________________________________________________________
>
>
> ______________________________________________
> Searchable message archive :
> http://groups.yahoo.com/group/chrom-l/messages
>
> Sites of interest :
> http://groups.yahoo.com/group/chrom-l/links
>
> To unsubscribe send email to :
> mailto:chrom-L-unsubscribe@yahoogroups.com
> ______________________________________________
>
>
> ------------------------------------------------------------------------
> Yahoo! Groups Links
>
>
>
>
> ------------------------------------------------------------------------
>
>
>
>

Hello All,

We are in the process of purchasing an ICP-MS. But I am confused by
all the technologies available in the market. Please suggest which
technology is better Dynamic Reaction Cell or Collision cell. Please
suggest.

Rajneesh