Woman With Perfect Memory Baffles Scientists

Patient Remembers Every Day and Almost Every Detail of Her Life
March 20, 2006 -- - James McGaugh is one of the world's leading
experts on how the human memory system works. But these days, he
admits he's stumped.

McGaugh's journey through an intellectual purgatory began six years
ago when a woman now known only as AJ wrote him a letter detailing
her astonishing ability to remember with remarkable clarity even
trivial events that happened decades ago.

Give her any date, she said, and she could recall the day of the
week, usually what the weather was like on that day, personal details
of her life at that time, and major news events that occurred on that
date.

Like any good scientist, McGaugh was initially skeptical. But not
anymore.

"This is real," he says.

Soon after AJ took over his life, McGaugh teamed with two fellow
researchers at the University of California at Irvine. Elizabeth
Parker, a clinical professor of psychiatry and neurology (and lead
author of a report on the research in the current issue of the
journal Neurocase), and Larry Cahill, an associate professor of
neurobiology and behavior, have joined McGaugh in putting AJ through
an exhaustive series of interviews and psychological tests. But they
aren't a lot closer today to understanding her amazing ability than
they were when they started.

"We are trying to find out, but we haven't hit 'bingo' yet," says
McGaugh.

His initial hypothesis, like several others, has turned out to be
wrong -- or at least incomplete.

McGaugh has spent decades studying how such things as stress hormones
and emotions affect memory, and at first he thought AJ's memories
were of such emotional power that she couldn't forget them.

But that hypothesis fell short of the mark when it became obvious
that "the woman who can't forget" remembers trivial details as
clearly as major events. Asked what happened on Aug 16, 1977, she
knew that Elvis Presley had died, but she also knew that a California
tax initiative passed on June 6 of the following year, and a plane
crashed in Chicago on May 25 of the next year, and so forth. Some may
have had a personal meaning for her, but some did not.

"Here's a woman who has very strong memories, but she has very strong
memories of things for which I have no memory at all," McGaugh says.

That became particularly clear one day when he asked her out of the
blue if she knew who Bing Crosby was.

"I wasn't sure she would know, because she's 40 and wasn't of the
Bing Crosby era," he says.

But she did.

"Do you know where he died?" McGaugh asked.

"Oh yes, he died on a golf course in Spain," she answered, and
provided the day of the week and the date when the crooner died.

When the researchers asked her to list the dates when they had
interviewed her, she "just reeled them off, bang, bang, bang."

She also told McGaugh that on the day after a particular interview,
which took place several years ago, he flew to Germany.

"I said what? I went to Germany? I couldn't even remember what year I
had gone to Germany," he says.

That level of recall suggests another hypothesis. Some people are
able to recall past events by categorizing them. Certain events, or
facts, are associated with others, and filed away together so that
they may be easier to access. That's a trick that is often used by
entertainers who use feats of memory to wow their audience.

AJ does have "some sort of compulsive tendencies. She wants order in
her life," McGaugh says. "As a child, she would get upset if her
mother changed anything in her room because she had a place for
everything and wanted everything in its place.

"So she does categorize events by the date, but that doesn't explain
why she remembers it."

Also, her degree of recall is so much greater than any other person's
in the scientific literature that it seems unlikely to be the
complete answer, McGaugh adds.

She is also quite different from savants who have surfaced from time
to time with extraordinary abilities in music, art or memory.

"Some of them can remember every single detail about the particular
hobby that they have, such as baseball or calendars or art, but they
are very narrow," he says. McGaugh described one person who could
memorize a piece of music instantly, and not forget it, but
who "couldn't make change or couldn't take a bus because he didn't
know where he was."

By contrast, AJ is a " fully functioning person," McGaugh says.

The researchers are preparing to take their work in a new direction
in hopes of understanding what is going on here. It's possible AJ's
brain is wired differently, and that may show up through magnetic
resonance imaging. Testing is expected to begin within six months.

"We will be looking at her brain, using brain scanning techniques, to
see if there's anything that is dramatically different that we can
point to," McGaugh says.

Those of us with normal, very fallible memories function somewhat
like a computer in that different areas of our brains are
interconnected and thus better-suited for general memories. We know
where we live and how to get to work, but we may not know what the
weather was like on this date four years ago.

It's possible that AJ's brain has some "disconnections" that help her
recall past events from her memory bank without interference from the
parts of her brain that act as general processors. But the problem is
that even if they find some interesting wiring through brain scans,
the researchers will be limited in their conclusions by the fact that
AJ seems to be unique.

So unique, in fact, that the Irvine team has given her condition a
new name. They call it hyperthymestic syndrome, based on the Greek
word thymesis for "remembering" and hyper, meaning "more than
normal."

Some day, the researchers say, they hope to know what's different
about AJ's brain, but they are still a ways off.

"In order to explain a phenomenon you have to first understand the
phenomenon," McGaugh says. "We're at the beginning."

<http://abcnews.go.com/Technology/print?id=1738881>