News in Science - Forgetful? Virus may be eating your brain - 24/10/2006

This is the print version of story
http://www.abc.net.au/science/news/stories/2006/1772157.htm
<http://www.abc.net.au/science/news/stories/2006/1772157.htm>
Forget where you left your glasses? Did those keys go missing again? A
virus may be to blame.

Viruses that cause a range of ills from the common cold to polio may be
able to infect the brain and cause steady damage, a team at the Mayo
Clinic <http://www.mayoclinic.com/> in Minnesota reports.

"Our study suggests that virus-induced memory loss could accumulate over
the lifetime of an individual and eventually lead to clinical cognitive
memory deficits," says Dr Charles Howe, who reports the findings in the
latest issue of the journal Neurobiology of Disease
<http://www.sciencedirect.com/science/journal/09699961> .

The viruses are called picornaviruses and infect more than 1 billion
people worldwide each year.

They include the virus that causes polio, as well as colds and
diarrhoea. People contract an average of two or three such infections a
year.

"We think picornavirus family members cross into the brain and cause a
variety of brain injuries. For example, the polio virus can cause
paralysis," Howe says.

"It can injure the spinal cord and different parts of the brain
responsible for motor function. In the [mouse] virus we studied, it did
the same thing and also injured parts of the brain responsible for
memory."

The researchers infected mice with a virus called Theiler's murine
encephalomyelitis virus, which is similar to human poliovirus.

Infected mice later had difficulty learning to navigate a maze. Some
were barely affected, while others were completely unable to manage.

When the mice were killed and their brains examined, a correlating
amount of damage was seen in the hippocampus region, related to learning
and memory.

One virus particularly likely to cause brain damage is enterovirus 71,
which is common in Asia, the researchers say.

It can cross over into the brain and cause encephalitis, a brain
inflammation that can lead to coma and death.

"Our findings suggest that picornavirus infections throughout the
lifetime of an individual may chip away at the cognitive reserve,
increasing the likelihood of detectable cognitive impairment as the
individual ages," the researchers write.

"We hypothesise that mild memory and cognitive impairments of unknown
aetiology may, in fact, be due to accumulative loss of hippocampus
function caused by repeated infection with common and widespread
neurovirulent picornaviruses."

Other viruses kill brain cells, including the herpes virus and HIV.
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<http://www.abc.net.au/science/news/stories/s911523.htm>


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