Welcome to the X-Lab!

Our lab is broadly interested in transmembrane and sesnory signaling based on channels, pursuing both biophysical mechanisms and bioengineering innovations.

One of the most important signaling pathways to convey information from external world into biological systems is by way of channels sitting across the membrane. Such channels: could be cued either by physical (e.g. voltage or photons) or by chemical signals (e.g. small molecules or ions); could be either natural channels (e.g. ion channels conductive to Ca2+ or K+) or engineered channels (e.g., nanopores by ultrasound). We mainly focus on fundamental mechanisms critical to channel complexes involved in transmembrane signaling, especially those related to sensory functions, such as vision and taste. Representative work toward this direction refers to Liu X. et. al. Nature. Meanwhile, we actively explore the potentials of novel methodologies developped or derived from our basic research, such as sonoporation, channel modulators, biomolecular sensors etc. relevant publications